Neohesperidin Dihydrochalcone NEW
| Price | $29 |
| Package | 1g |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Neohesperidin Dihydrochalcone | CAS No.: 20702-77-6 |
| Purity: 99.8% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Neohesperidin Dihydrochalcone |
| Description | Neohesperidin Dihydrochalcone (Neohesperidin DC) is an artificial sweetener derived from citrus. |
| Cell Research | WST-8 dye is used in the cell viability assay. HIT-T15 and HUVEC cells are grown and maintained in Dulbecco's modified Eagle's medium, supplemented with 10% fetal bovine calf serum. 1000 cells in each well are incubated with various concentrations of neohesperidin dihydrochalcone (50, 100, 500 μM, 1 mM) and other compounds. After treating HIT-T15 and HUVEC cells with 500 μM HOCl, WST-8 dye is added to each well, and the absorbance is detected at 420 nm with microplate reader[1]. |
| In vivo | Administration of neohesperidin dihydrochalcone significantly reduces the activities of AST and ALT, both key markers of liver damage. It also inhibits the expression of NF-κB, IL-6, IL-1β, and TNF-α proteins, which are elevated in the liver of PQ-treated mice, indicating its potential protective effects on liver inflammation and damage[3]. Furthermore, studies on Wistar Crl:(WI)WU BR rats to assess the embryotoxicity and teratogenicity of neohesperidin dihydrochalcone reveal no adverse effects at dietary levels up to 5%, the highest dose investigated. At this level, rats consumed approximately 3.3 g/kg body weight/day[4], demonstrating the compound's safety at significant dosage levels. |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 100 mg/mL (163.24 mM) DMSO : 50 mg/mL (81.62 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | Neohesperidin Dihydrochalcone | Reactive Oxygen Species | Inhibitor | inhibit |
| Inhibitors Related | Imeglimin hydrochloride | Acetylcysteine | L-Ascorbic acid |
| Related Compound Libraries | Flavonoid Natural Product Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library | Natural Product Library for HTS | Anti-Aging Compound Library | Cosmetic Ingredient Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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