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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Neuronal Signaling>Adrenergic Receptor Inhibitors>Nebivolol hydrochloride
Nebivolol hydrochloride
  • Nebivolol hydrochloride

Nebivolol hydrochloride NEW

Price $43 $63 $97
Package 10mg 25mg 50mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Nebivolol hydrochloride CAS No.: 152520-56-4
Purity: 99.85% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameNebivolol hydrochloride
DescriptionNebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.
Cell ResearchCells are exposed to different concentrations of Nebivolol (10-7~10-5 M) for 1, 2, 4, 7 and 14 days. Cell proliferation is analyzed by bromodeoxyuridine (BrdU) incorporation, and cell apoptosis is detected by PI or annexin V staining.(Only for Reference)
In vitroNebivolol treatment of rats with myocardial infarction lowered mean blood pressure by a small amount. Nebivolol reduced myocardial apoptosis in rats with myocardial infarction when administered intravenously for 10 minutes followed by oral administration.
In vivoNebivolol reduced the proliferation of coronary smooth muscle cells (haCSMCs) and endothelial cells (haECs) in a concentration- and time-dependent manner.Nebivolol acted with high affinity and selectivity at the beta 1-adrenergic receptor site in the preparation of rabbit lung membranes.Nebivolol treatment of haCSMCs for 7 days significantly inhibited cell proliferation (IC50 ~ 10 μM). Nebivolol treated haCSMCs for 7 days, significantly inhibited cell proliferation (IC50: 6.1 μM). nebivolol treated haCSMCs for 48 hours, the apoptosis rate was 23%, and reduced the number of S-phase cells.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationEthanol : 4.4 mg/mL (10 mM)
DMSO : 60 mg/mL (135.78 mM), Sonication is recommended.
KeywordsR-065824 Hydrochloride | adrenergic blocking | Adrenergic Receptor | ischemic heart disease | R65824 | R 065824 | congestive heart failure | coronary artery disease | R065824 | Nebivolol | oral | inhibit | hypertension | R 065824 Hydrochloride | Nebivolol hydrochloride | Inhibitor | R065824 Hydrochloride | Beta Receptor | vasodilator | R 65824 | Apoptosis | R-065824 | Nebivolol Hydrochloride
Inhibitors RelatedStavudine | 5-Fluorouracil | Acetylcysteine | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin
Related Compound LibrariesHighly Selective Inhibitor Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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