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Postion:Product Catalog >NDB
NDB
  • NDB

NDB NEW

Price $99
Package 1mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-21

Product Details

Product Name: NDB CAS No.: 1660153-08-1
Purity: 98.94% Supply Ability: 10g
Release date: 2024/11/21

Product Introduction

Bioactivity

NameNDB
DescriptionNDB is a selective and potent hFXRα antagonist that inhibits GW4064-stimulated FXR/RXR interactions and FXRα target gene expression in primary mouse hepatocytes.NDB is used in the study of diabetes.
In vitroNDB induces rearrangements of helix 11 (H11) and helix 12 (H12, AF-2) by forming a homodimer of hFXRα-LBD, differing significantly from the active monomer conformation[1]. At 25 μM, NDB effectively antagonizes the GW4064-stimulated FXR/RXR interaction and FXRα target gene expression in primary mouse hepatocytes, including the small heterodimer partner (SHP) and bile-salt export pump (BSEP)[1].'
In vivoAdministered through intraperitoneal injection at a dosage of 24 mg/kg once a day for a duration of 4 weeks, NDB efficiently decreases the gene expressions of phosphoenolpyruvate carboxykinase (PEPCK), glucose 6-phosphatase (G6-pase), small heterodimer partner, and bile-salt export pump (BSEP) in db/db mice[1].
Storagestore at low temperature | Shipping with blue ice.
Solubility InformationDMSO : 80 mg/mL (169.70 mM), Sonication is recommended.
Inhibitors RelatedForskolin | Ursodeoxycholic acid sodium | Altenusin | T0901317 | Obeticholic Acid | Lithocholic acid | Chenodeoxycholic acid | Sevelamer hydrochloride | GW 4064 | Hyodeoxycholic acid | GSK2324 | DY268

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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