Product Details
Product Name:
NCGC00378430 |
CAS No.:
920650-00-6 |
Purity:
99.74% |
Supply Ability:
10g |
Release date:
2024/11/18 |
Product Introduction
Bioactivity
名稱 | NCGC00378430 |
描述 | NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor that disrupts the [SIX1/EYA2] complex, EMT, and metastasis. |
體外活性 | NCGC00378430 reduces the SIX1/EYA2 interaction.?8430 partially reversed transcriptional and metabolic profiles mediated by SIX1 overexpression and reversed SIX1-induced TGFβ signaling and EMT. |
體內(nèi)活性 | NCGC00378430?was well tolerated when delivered to mice and significantly suppressed breast cancer associated metastasis in vivo without significantly altering primary tumor growth. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 90 mg/mL (203.85 mM), Sonication is recommended.
|
關(guān)鍵字 | Inhibitor | T47D | E-CAD | MCF7 | Phosphatase | TGF-β | NCGC00378430 | inhibit | SIX1 | p-Smad3 | breast | EMT | cancer | FN1 | transcriptional | NCGC 00378430 | NCGC-00378430 | EYA2 |
相關(guān)產(chǎn)品 | PTP1B-IN-22 | Disodium monofluorophosphate | β-Glycerophosphate disodium salt pentahydrate | MLS000544460 | Tartaric acid disodium dihydrate | Cyclosporine | Stearic acid | Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride | L-Ascorbic acid 2-phosphate magnesium | Cyclosporin A | Trimyristin | β-Glycerophosphate disodium salt hydrate |
相關(guān)庫 | 糖代謝化合物庫 | 經(jīng)典已知活性庫 | 抗乳腺癌化合物庫 | 抑制劑庫 | 代謝化合物庫 | 已知活性化合物庫 | 抗癌化合物庫 | 磷酸酶抑制劑化合物庫 | 抗癌活性化合物庫 | TGF-β/Smad靶點化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |