NBD-125 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: NBD-125 | CAS No.: 2367641-24-3 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | NBD-125 |
| Description | NBD-125 (B-12) is a berberine analogue. NBD-125 is an RXRα activator. The IC50 value of NBD-125 in KM12C cell is 31.10 μM [1]. |
| In vitro | NBD-125 (B-12) demonstrates a potent ability to activate RXRα transcription and significantly suppresses colon cancer cell proliferation, making it an effective inhibitor of β-catenin signaling. Its anti-proliferative effects are observed across a range of concentrations (0-80 μM) in several colon cancer cell lines, including Km12c, HCT116, and SW620. Detailed Western Blot Analysis reveals that, after a 15-hour incubation period across varying concentrations (0-50 μM, 0-60 μM, 0-80 μM), there is a notable decrease in c-Myc and Cdc42 protein levels, indicating a disruption in cellular signaling pathways critical for cancer cell growth. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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