N-Ethylmaleimide NEW
| Price | $39 | $62 | $82 |
| Package | 10mg | 25mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: N-Ethylmaleimide | CAS No.: 128-53-0 |
| Purity: 99.92% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | N-Ethylmaleimide |
| 描述 | N-Ethylmaleimide (NEM) is a reagent for alkylation of free sulfhydryl groups, a cysteine protease inhibitor used in experimental biochemistry. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor that specifically inhibits phosphate transport in mitochondria. |
| 體外活性 | METHODS: Growth-arrested VSMC cells were treated with N-Ethylmaleimide (20 μM) and PDGF-BB (20 ng/mL) for 5 min - 2 h, and the expression levels of target proteins were detected by Western Blot. RESULTS: N-Ethylmaleimide inhibited PDGF BB-stimulated Akt phosphorylation. [1] METHODS: Jurkat T cells were treated with N-Ethylmaleimide (3-100 μM) for 1-20 min, and target protein expression levels were detected by immunoblots. RESULTS: Treatment of intact cells with 50-100 μM N-Ethylmaleimide for 5-10 min resulted in a significant increase in tyrosine residue phosphorylation. [2] |
| 體內(nèi)活性 | METHODS: To examine the potential enhancement of sleep properties induced by alprazolam (Alp), N-Ethylmaleimide (1 mg/kg, 1% CMC-Na) and Alp (1.84 mg/kg, 1% CMC-Na) were administered by gavage to C57BL/6J mice. RESULTS: Combined administration of Alp and NEM significantly reduced sleep latency and prolonged sleep duration compared with Alp alone. This effect was characterized by a significant increase in REM duration. [3] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | 5% DMSO+95% Saline : 1.2 mg/mL (9.59 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO : 60 mg/mL (479.5 mM) |
| 關(guān)鍵字 | Deubiquitinase | inhibit | VSMC | Apoptosis | N-Ethylmaleimide | DUBs | cysteine residue | NEthylmaleimide | N Ethylmaleimide | phosphate transport | sulfhydryl | Cathepsin | Inhibitor | modify |
| 相關(guān)產(chǎn)品 | Papain | 2-Aminoethanethiol |
| 相關(guān)庫 | 高選擇性抑制劑庫 | DNA 損傷和修復(fù)分子庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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