Product Details
| Product Name:
MSDC 0160 |
CAS No.:
146062-49-9 |
| Purity:
99.53% |
Supply Ability:
10g |
| Release date:
2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | MSDC 0160 |
| 描述 | MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease. |
| 激酶實(shí)驗(yàn) | Measurement of activities of autophosphorylated/non-autophosphorylate CaMKII: CaMKII activity is measured utilizing syntideII as a substrate. Purified CaMKII is pre-incubated in the assay mixture ( 35 mM Hepes-Na ( pH 8.0 ), 10 mM MgC12, 0.5 μM CaM, 5 μM ATP, 1 mM CaCl2 or 1 mM EGTA, total 25 μL) at 30 °C for 2 minutes. After this pre-incubation, the protein substrate/radioactive ATP mixture is added to the same test tube and the preparation is further incubated at 30 °C, for 5 minutes ( final assay condition; 35 mM Hepes-Na (pH 8.0), 10 mM MgCl2, 0.125 μM CaCl2, 20 μM syntideII, 11.25 μM [ γ-32P] ATP, 10 % DMSO and indicated concentrations of KN-93, supplemented with 0.25 mM CaCl2 and 2 mM EGTA (for autophosphorylated samples) or 0.25 mM EGTA and 2 mM CaCl2 (for nonautophosphorylated samples ), total 100 μL ). The reaction is terminated by adding of 25 μL of 100 % ( w/v ) ice-cold TCA. After centrifugation, 80 μL of the supernatant is applied to phosphocellulose paper. The filters are then washed with 75 mM H3P04 for 15 min with continuous agitation. After 4-cycles of washing, the radioactivity retains on the filter paper is quantified in a liquid scintillation counter. |
| 體外活性 | In the KKAy mouse model of diabetes, MSDC-0160 (100 mg/kg, p.o.) significantly enhanced insulin sensitivity by substantially reducing the levels of insulin and glucose in the circulatory system. |
| 體內(nèi)活性 | Within the insulin and IGF-1 signaling pathways, MSDC-0160 reduces resistance and restores IGF-1-induced phosphorylation of AKt and GSK-3. When used in conjunction with IGF-1 and 8 mM glucose, MSDC-0160 boosts the expression of specific genes within β-cells, including insulin, pdx1, nkx6.1, and nkx2.2, while maintaining insulin content without affecting glucose-induced insulin secretion. Additionally, MSDC-0160 promotes the differentiation of human β-cells and decreases the expression of apoptosis markers. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 37 mg/mL (100 mM)
|
| 關(guān)鍵字 | mTOT | antidiabetic | pyruvate | CAY 10415 | MPC | insulin | Insulin Receptor | MSDC 0160 | thiazolidinedione | inhibit | Inhibitor | Mitochondrial Metabolism | sensitizer | neuroprotective | carrier | CAY-10415 | Alzheimer | mitochondrial |
| 相關(guān)產(chǎn)品 | Imeglimin hydrochloride | Rotenone | Glibenclamide | Tricarballylic acid | Thiabendazole | Boscalid | α-Lipoic Acid | (-)-Epigallocatechin Gallate | Lipoic acid | Daidzin | D-Histidine | Nerol |
| 相關(guān)庫 | 神經(jīng)退行性疾病化合物庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 酪氨酸激酶分子庫 | 激酶抑制劑庫 | 抗癌臨床化合物庫 | 神經(jīng)保護(hù)化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$2500.00/100mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-10-28 |
United States