MS8511 HCl NEW
| Price | $195 | $483 | $692 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: MS8511 HCl | Purity: 98.90% |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | MS8511 HCl |
| Description | MS8511 HCl is a selective and potent covalent inhibitor of G9a/GLP that acts by targeting cysteine residues in the substrate binding site. MS8511 has anticancer activity and antiproliferative activity and reduces intracellular H3K9me2 levels.MS8511 can be used to study a wide range of cancers including brain, breast, and ovarian cancers . |
| In vitro | MS8511 HCl (Compound 8), within a range of 0-100 μM over 10 minutes, selectively inhibits G9a and GLP compared to other PKMTs and PRMTs, with IC50 values of 100 nM (G9a) and 140 nM (GLP) [1].With a duration of 50 minutes, MS8511 HCl exhibits a preference for covalent modification of G9a over GLP, with Kd values of 44 nM (G9a) and 46 nM (GLP) [1].Over a range of 0-5 μM and durations of 24-72 hours,MS8511 HCl effectively reduces the H3K9me2 mark in MDA-MB-231 and K562 cells [1]. At concentrations ranging from 0.8 to 25 μM over a period of 3 days, MS8511 HCl inhibits the growth of MDA-MB-231 cells [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | MS8511HCl（2866408219Freebase） |
| Inhibitors Related | BIX-01294 trihydrochloride | Tazemetostat | Piribedil | XY1 | UNC 0631 | GSK126 | EPZ015666 | AMI-1 free acid | MS37452 | MRTX-1719 |
| Related Compound Libraries | Bioactive Compound Library | Epigenetics Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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