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Postion:Product Catalog >Motixafortide TFA(664334-36-5,Free)
Motixafortide TFA(664334-36-5,Free)
  • Motixafortide TFA(664334-36-5,Free)

Motixafortide TFA(664334-36-5,Free) NEW

Price $68 $198 $297
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-15

Product Details

Product Name: Motixafortide TFA(664334-36-5,Free) Purity: 100%
Supply Ability: 10g Release date: 2024/11/15

Product Introduction

Bioactivity

名稱Motixafortide TFA(664334-36-5,Free)
描述Motixafortide TFA(664334-36-5,Free) (BKT140 TFA) is an antagonist of CXCR4 with IC50 of ~1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.
體外活性Treatment with Motixafortide induces the robust mobilization of AML blasts from the BM. In addition, AML cells exposed to Motixafortide undergoes differentiation. Motixafortide induces the apoptosis of AML cells in vitro, which is mediated by the up-regulation of miR-15a/miR-16-1, resulting in down-regulation of the target genes BCL-2, MCL-1 and cyclin-D1. Overexpression of miR-15a/miR-16-1 directly induces leukemic cell death. Motixafortide-induced apoptosis is also mediated by the inhibition of survival signals via the AKT/ERK pathways.
體內(nèi)活性Motixafortide also synergizes with FLT3 inhibitors to induce AML cell death. Importantly, this combined treatment prolongs the survival of tumor-bearing mice and reduces minimal residual disease in vivo.
存儲條件keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度H2O : 100 mg/mL (46.31 mM), Sonication is recommended.
DMSO : 100 mg/mL (46.31 mM)
關(guān)鍵字Motixafortide TFA(664334 36 5,Free) | Motixafortide TFA(664334-36-5,Free) | Motixafortide TFA(664334365,Free)
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Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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