Montelukast sodium NEW
Price | Get Latest Price |
Package | 1kg |
Min. Order: | 1kg |
Supply Ability: | 20tons |
Update Time: | 2024-04-18 |
Product Details
Product Name: Montelukast sodium | CAS No.: 151767-02-1 |
EC-No.: 604-813-7 | Min. Order: 1kg |
Purity: 99% | Supply Ability: 20tons |
Release date: 2024/04/18 |
Items | Standard | Results |
APPEARANCE | Off white to white powder | White powder |
IDENTIFICATION | A: IR B: Retention time | Complies Complies |
WATER | ≤0.5% | 0.06% |
HEAVY METALS | ≤0.002% | Complies |
ISOMERS | SFBD1≤0.15% | Undetected |
SFBD2≤0.15% | Undetected | |
SFBE≤0.15% | Undetected | |
RELATED SUBSTANCES | SFBA-1≤0.15% | 0.04% |
SFBMA≤0.15% | Undetected | |
CHLORO-SFB≤0.15% | 0.05% | |
DiSFBMA-SFB≤0.15% | 0.02% | |
Methyl-SFB≤0.15% | Undetected | |
Pentafluoro-phenol≤0.15% | Undetected | |
Amino-SFB≤0.15% | Undetected | |
Any unknown impurity≤0.1% | 0.04% | |
Total impurity≤1.0% | 0.21% | |
RESIDUE SOLBENTS | Methanol≤3000ppm | Undetected |
Isopropyl alcohol≤5000ppm | 19ppm | |
Dichloromethane≤600ppm | Undetected | |
Tetrahydrofuran≤720ppm | Undetected | |
Acetic acid≤5000ppm | Undetected | |
Toluene≤890ppm | Undetected | |
Chlorobenzene≤360ppm | Undetected | |
Methyl tert-butyl ether≤5000ppm | 103ppm | |
ASSAY | ≥99.0% | 99.8% |
Product Name: Montelukast sodium
Synonyms: singulair;MONTELUKAST NA;MONTELUKAST SODIUM;mk-476;2-[1-[[1-[3-[2-[(7-chloro-2-quinolyl)]vinyl]phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)phenyl]-propyl]sulfanylmethyl]cyclopropyl]acetic acid sodium salt;1-[1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic;MK-476, Singulair;Montelukast, Sodium Salt
CAS: 151767-02-1
MF: C35H35ClNNaO3S
MW: 608.17
EINECS: 604-813-7
Melting point: 115 °C(dec.)
Storage temp.: -20°C Freezer, Under Inert Atmosphere
Description:
Montelukast was launched as Singulair in Mexico and Finland for the management of mild to moderate asthma inadequately controlled by inhaled corticosteroids and short-acting beta2-agonists. Montelukast can be obtained by an seven-step synthesis from 3-[2(E)-(7-chloroquinolin-2-yl)vinyl] benzaldehyde. Montelukast is a potent, selective and orally active antagonist of the CysLT1 (formerly called LTD4) receptor, thus blocking the effects of the cysteinyl leukotrienes LTC4, LTD4 and LTE4 on microvascular permeability and the activation of eosinophils.
Montelukast represents the third molecule of this class which has been approved in asthma after pranlukast (1995) and zafirlukast (1996). Montelukast has been studied extensively in placebo-controlled clinical trials, in mildly or severe asthmatic patients challenged with LTD4 or exercise. A variety of acute bronchoconstricting challenges were inhibited or attenuated with all doses used.
Montelukast demonstrated clinically significant improvements in the parameters of asthma control associated with an appreciable improvement in quality of life., reducing days with asthma exacerbations and allowing significant tapering of corticosteroids. Montelukast is well-tolerated and only needs to be administered once a day.
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