MMPIP hydrochloride NEW
| Price | $54 | $79 | $128 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: MMPIP hydrochloride | CAS No.: 1215566-78-1 |
| Purity: 99.26% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | MMPIP hydrochloride |
| Description | MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system functions. |
| In vitro | In CHO cells coexpressing rat mGluR7 with Gα15, MMPIP hydrochloride inhibits L-(+)-2-amino-4-phosphonobutyric acid (L-AP4; 0.5 mM)-induced intracellular Ca2+ mobilization with an IC50 of 26 nM. MMPIP hydrochloride also antagonizes L-AP4-induced inhibition of cAMP accumulation with an IC50 of 610 nM. MMPIP hydrochloride inhibits L-AP4-induced inhibition of forskolin-stimulated cAMP accumulation in CHO cells expressing rat mGluR7[1]. |
| In vivo | MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice. MMPIP hydrochloride (10 mg/kg; i.p.) rescues the MK-801 (0.1 mg/kg)-induced cognitive impairments, by improving the choice accuracy. MMPIP hydrochloride (10 mg/kg) attenuates the amplitude of the acoustic startle response and markedly enhances the prepulse-induced inhibition of the acoustic startle response (up to 137% of control)[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 3.7 mg/mL (10 mM), Sonication is recommended. |
| Keywords | 479077-02-6 | MMPIP Hydrochloride | MMPIP hydrochloride | MMPIP | system | nervous | neuropathic | behavior | pain | inhibit | central | glutamate | cognitive | allosteric | Metabotropic glutamate receptors | 479077-02-6 Free base | Inhibitor | metabotropic | mGluR | mGluR7 |
| Inhibitors Related | IDRA-21 | Topiramate | Decanoic Acid | Urethane | L-Cysteic acid monohydrate | Evans blue | L-Glutamine | Direct Blue 1 | L-Glutamic acid monosodium salt | Piracetam | O-Phospho-L-serine | Memantine hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | Neuroprotective Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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