MMAD NEW
| Price | $40 | $70 | $133 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: MMAD | CAS No.: 203849-91-6 |
| Purity: 99.91% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | MMAD |
| Description | MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs). |
| In vitro | MMAD (Monomethyl Dolastatin 10) undergoes a stable oxime-ligation to produce several nearly homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of approximately 2.0. These conjugates exhibit favorable pharmacokinetic properties and potent in vitro cytotoxicity against HER2+ cancer cells. Furthermore, ADCs synthesized using site-specific unnatural amino acids display enhanced in vitro cytotoxicity compared to those prepared through cysteine alkylation after native interchain disulfide reduction. |
| In vivo | The resulting antibody-drug conjugates (ADCs) demonstrated complete tumor regression in rodents and showed an improved toxicology profile in rats. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 24.5 mg/mL (31.77 mM), Sonication and heating are recommended. |
| Keywords | inhibit | Demethyldolastatin-10 | Demethyldolastatin10 | MMAD | Monomethyl Dolastatin-10 | Inhibitor | Microtubule/Tubulin | ADC Payload | Monomethyl Dolastatin10 | ADC Cytotoxin |
| Inhibitors Related | Methotrexate | Flubendazole | Mebendazole | N-Phenylbenzylamine | 4-Isopropoxybenzoic acid | Dexamethasone acetate | Oxfendazole | Methylene Blue trihydrate | Paclitaxel |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36?Washington?Street, Wellesley?Hills
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