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Postion:Product Catalog >ML-180
ML-180
  • ML-180

ML-180 NEW

Price $30 $44 $70
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-18

Product Details

Product Name: ML-180 CAS No.: 863588-32-3
Purity: 99.74% Supply Ability: 10g
Release date: 2024/11/18

Product Introduction

Bioactivity

名稱ML-180
描述ML-180 (SR1848) is a potent inverse agonist of the orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) with an IC50 of 3.7 μM.
體外活性ML-180 (0.5-5 μM; 24 hours) shows a significant inhibition of cyclin-D1 and cyclin-E1 expression in hepatic cells, but has little effect on repression in SK-OV-3 cells[2]. ML-180 (5 μM; 24 hours) leads to a rapid decrease of LRH-1 expression and efficiently represses endogenous LRH-1 signaling[2].
體內(nèi)活性ML-180 has a statistically significant decrease of both LRH-1 and SHP mRNA in adrenal glands and pancreatic tissue[2].
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 11 mg/mL (28.28 mM), Sonication is recommended.
關(guān)鍵字SR-1848 | steroidogenic | Inhibitor | Orphan | ML-180 | factor-1 | LRH-1 | cancers | nuclear | NR5A2 | NR5A1 | inhibit | homolog | liver | ML180 | SR 1848 | receptor | ML 180 | SF-1
相關(guān)庫(kù)核受體化合物庫(kù) | 經(jīng)典已知活性庫(kù) | NO PAINS 化合物庫(kù) | 已知活性化合物庫(kù) | 抗癌化合物庫(kù) | 抗癌活性化合物庫(kù)

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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Recommended supplier

Product name Price   Suppliers Update time
$60.00/2mg
VIP3Y
TargetMol Chemicals Inc.
2024-10-23
$5.00/1KG
VIP2Y
Henan Fengda Chemical Co., Ltd
2024-03-27
$30.00/1mg
VIP3Y
TargetMol Chemicals Inc.
2024-11-18
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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