Product Details
| Product Name:
MKC8866 |
CAS No.:
1338934-59-0 |
| Purity:
99.35% |
Supply Ability:
10g |
| Release date:
2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | MKC8866 |
| 描述 | MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29 μM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibit prostate cancer (PCa) tumor growth. |
| 體外活性 | MKC8866 strongly suppresses DTT-induced X-box-binding protein 1-spliced (XBP1s) expression (EC50: 0.52?μM) and unstressed RPMI 8226 cells (IC50: 0.14?μM). MKC8866 (0.2-10 μM; 3 days) inhibits the viability of all four cell lines in a dose-dependent manner under normal conditions, with the most robust effect in LNCaP cells, and MKC8866 (20 μM; 72?hours) is sufficient to completely block NSC 125973-induced expression of XBP1s [1]. MKC8866 (20?μM; 6 days) reduces the proliferation of all breast cancer cell lines and MKC8866 (20 μM; 48 hours) decreases the number of cells entering the S phase [2]. |
| 體內(nèi)活性 | MKC8866 (oral; 300 mg/kg; for 28 days) reduces tumor regrowth following NSC 125973 withdrawal [1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 3.61 mg/mL (10 mM), Sonication is recommended.
|
| 關(guān)鍵字 | Inositol requiring enzyme 1 | inhibit | MKC8866 | IRE1 | Inhibitor | MKC-8866 | MKC 8866 |
| 相關(guān)產(chǎn)品 | B I09 | Sunitinib | 6-Bromo-2-hydroxy-3-methoxybenzaldehyde | Sunitinib Malate | D-F07 | STF-083010 | APY29 | GSK2850163 (S enantiomer) | 4μ8C | GSK2850163 | Toyocamycin | IXA4 |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 激酶抑制劑庫 | 抗乳腺癌化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 細胞周期化合物庫 | 共價抑制劑庫 | 臨床前化合物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States