天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
+1 (818) 612-2111
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >Biochemical Engineering>Inhibitors>Cell Cycle>Aurora Kinase Inhibitors>MK-8745
MK-8745
  • MK-8745

MK-8745 NEW

Price $34 $51 $91
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: MK-8745 CAS No.: 885325-71-3
Purity: 99.31% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameMK-8745
DescriptionMK-8745 is a potent and selective Aurora A inhibitor.
In vivoMK-8745 induces apoptosis in a p53-dependent manner across various cell lines in vitro. Exposure of p53 wild-type cells to MK-8745 leads to the induction of p53 phosphorylation (ser15) and an increase in p53 protein expression. This p53-dependent apoptotic effect of MK-8745 is further confirmed in HCT 116 p53 (-/-) cells transfected with wild-type p53. In non-Hodgkin's lymphoma cell lines, MK-8745 causes cell cycle arrest at the G2/M phase with the accumulation of tetraploid nuclei, followed by cell death. Treatment with MK-8745 induces p21 (waf1/cip1) and CycB1, indicating cell cycle arrest and an increased population of cells in the G2/M phase. Additionally, MK-8745 treatment leads to the rapid degradation of Aurora-A substrates (TACC3, Eg5, and TPX2) following the reduction of phospho-Aurora-A.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationH2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 1 mg/mL (2.31 mM)
DMSO : 55 mg/mL (127.34 mM), Sonication is recommended.
KeywordsMK8745 | Inhibitor | inhibit | Aurora Kinase | Apoptosis | MK-8745 | MK 8745
Inhibitors RelatedStavudine | 5-Fluorouracil | Acetylcysteine | Kaempferol | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin | Lidocaine hydrochloride
Related Compound LibrariesHighly Selective Inhibitor Library | Apoptosis Compound Library | Bioactive Compound Library | Epigenetics Compound Library | Kinase Inhibitor Library | Inhibitor Library | NO PAINS Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Fluorochemical Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$0.00/1G
VIP1Y
CONTIDE BIOTECH CO.,LTD
2024-03-25
$99.00/1g
VIP4Y
Shanghai UCHEM Inc.
2023-11-14
$0.00/50g
VIP3Y
HangZhou RunYan Pharma Technology Co.,LTD.
2024-09-20
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
INQUIRY