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Postion:Product Catalog >API>Antineoplastic agents>Antitumor Adjuvant Drugs>Mitoxantrone dihydrochloride
Mitoxantrone dihydrochloride
  • Mitoxantrone dihydrochloride

Mitoxantrone dihydrochloride NEW

Price $50 $72 $183
Package 50mg 100mg 500mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Mitoxantrone dihydrochloride CAS No.: 70476-82-3
Purity: 99.85% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameMitoxantrone dihydrochloride
DescriptionMitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor.
Cell ResearchThe human breast carcinoma cell lines MDA-MB-231 and MCF-7 are seeded in standard 96-well plates. One day after seeding, the culture medium is changed and replaced by medium containing different concentration of Mitoxantrone (10-5 to 5 μM) with or without DHA (30 μM) during 7 days. Viability of cells are measured as a whole by the tetrazolium salt assay[3].
In vitroIn a murine air pouch model of inflammation, methotrexate demonstrated an inhibitory concentration 50 (IC50) of 0.08 mg/kg per week.
In vivoMethotrexate inhibits the de novo synthesis of purines and pyrimidines, the formation of polyamines, and the transmethylation reactions of DNA, RNA, phospholipids, and proteins. It suppresses the enzyme thymidylate synthase, leading to a deficiency of thymidylate inside cells, which ultimately results in antiproliferative cytotoxicity. Methotrexate enters cells either through active transport or facilitated diffusion and, once inside, polyglutamation inhibits dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 38.8 mg/mL (75 mM)
H2O : 2.6 mg/mL (5 mM)
KeywordsB-CLL cells | NSC 301739 | MCF-7 | Endogenous Metabolite | Orthopoxvirus | Inhibitor | Mitoxantrone dihydrochloride | breast cancer | Apoptosis | lymphocytes | leukaemia | mitozantrone | Topoisomerase | Protein kinase C | mitozantrone Dihydrochloride | NSC301739 | inhibit | Mitoxantrone Dihydrochloride | PKC | antitumor | Mitoxantrone | Mitozantrone | HL60 cells | Mitoxantrone Hydrochloride
Inhibitors RelatedBerberine chloride | EIDD-1931 | Flumequine | Norfloxacin | α-Vitamin E | Prulifloxacin | Enoxacin | Ciprofloxacin | Ciprofloxacin monohydrochloride | Etoposide
Related Compound LibrariesAnti-Neurodegenerative Disease Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | FDA-Approved Kinase Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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