Milrinone NEW
| Price | $36 | $52 | $81 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Milrinone | CAS No.: 78415-72-2 |
| Purity: 99.93% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Milrinone |
| Description | Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor. |
| In vitro | Milrinone is a potent (IC50: 0.16-0.90 μM) and selective (100-fold more potent than peak I) inhibitor of peak III. Milrinone markedly increased cAMP levels and was accompanied by marked vasodilation. The increase in cAMP levels in rabbit coronary artery smooth muscle cells was also concentration-dependent. The concentration-dependent increase in cAMP levels was similar in rabbit and human platelets.Milrinone inhibited human platelet aggregation (IC50: 2 mM). Milrinone increased intracellular cyclic AMP concentrations through an inhibitory effect on type III phosphodiesterase. |
| In vivo | Milrinone is a potent (IC50: 0.16-0.90 μM) and selective (100-fold more potent than peak I) inhibitor of peak III. Milrinone markedly increased cAMP levels and was accompanied by marked vasodilation. The increase in cAMP levels in rabbit coronary artery smooth muscle cells was also concentration-dependent. The concentration-dependent increase in cAMP levels was similar in rabbit and human platelets.Milrinone inhibited human platelet aggregation (IC50: 2 mM). Milrinone increased intracellular cyclic AMP concentrations through an inhibitory effect on type III phosphodiesterase. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (213.05 mM), Sonication is recommended. |
| Keywords | Win-47203 | Win47203 | inhibit | Inhibitor | Milrinone | Phosphodiesterase (PDE) |
| Inhibitors Related | Theophylline monohydrate | Roflumilast | Theobromine | Apremilast | Isoprenaline hydrochloride | Indomethacin | Icariin | Theophylline | Vardenafil hydrochloride | Doxofylline |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Drug-Fragment Library | Inhibitor Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Bioactive Lipid Compound Library | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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