天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
+1 (818) 612-2111
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >MI-503
MI-503
  • MI-503

MI-503 NEW

Price $117 $219 $366
Package 2mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-11

Product Details

Product Name: MI-503 CAS No.: 1857417-13-0
Purity: 99.99% Supply Ability: 10g
Release date: 2024/11/11

Product Introduction

Bioactivity

名稱MI-503
描述MI-503 is an efficient and selective Menin-MLL inhibitor with an IC50 of 14.7 nM. In human MLL leukemia cell lines, MI-503 has a significant growth inhibition effect (GI = 250 nM-570 nM).
細(xì)胞實(shí)驗(yàn)Leukemia cells are treated with MI-503 or 0.25% DMSO and cultured at 37 °C for 7 days. Media is changed on day 4, viable cell numbers are restored to the original concentration and MI-503 are re-supplied. MTT cell proliferation assay kit is then employed, and plates are read for absorbance at 570 nm using a microplate reader.
動(dòng)物實(shí)驗(yàn)For efficacy studies in MV4;11 subcutaneous xenograft mice model, 5×10^6 cells are injected into the 4-6 week old female BALB/c nude mice. Treatment is started when the tumor size reached ~100 mm^3. Vehicle (25% DMSO, 25% PEG400, 50% PBS) or compounds (MI-463 or MI-503) are administrated once daily at designated doses using i.p. injections.
體外活性Treatment of murine bone marrow cells (BMC) transformed with the mLL-AF9 oncogene with MI-503 results in substantial growth inhibition (GI50: 0.22 μM). The cell growth inhibitory effect of MI-503 is time-dependent, with a pronounced effect achieved after 7-10 days of treatment.
體內(nèi)活性Following a single intravenous or oral administration, MI-503 rapidly attains high concentrations in peripheral blood and demonstrates significant oral bioavailability (75%). This compound effectively suppresses tumor growth through daily intraperitoneal (i.p.) doses, leading to an over 80% decrease in MV4;11 tumor volume, including complete regression in two mice. Continuous treatment over ten days notably delays the progression of mLL leukemia and substantially lowers the leukemia tumor burden in mice. Additionally, combined use of MI-503 and MI-463 significantly diminishes the expression of Hoxa9 and Meis1, indicating a potent antitumor activity.
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 45 mg/mL (79.7 mM), Sonication is recommended.
H2O : Insoluble
關(guān)鍵字Inhibitor | inhibit | MI 503 | MI503 | Epigenetic Reader Domain | MI-503
相關(guān)產(chǎn)品ABBV-744 | 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one | (+)-JQ-1 | Tazemetostat | Piribedil | GSK126 | Curcumin | EPZ015666 | dBET6 | Naphthol AS-E | MRTX-1719 | Bisdemethoxycurcumin
相關(guān)庫(kù)組蛋白修飾化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 表觀遺傳庫(kù) | 染色質(zhì)修飾分子庫(kù) | 抑制劑庫(kù) | 干細(xì)胞分化化合物庫(kù) | PPI抑制劑庫(kù) | 口服活性化合物庫(kù) | 已知活性化合物庫(kù) | 共價(jià)抑制劑庫(kù)

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$2780.00/50mg
VIP1Y
TargetMol Chemicals Inc.
2024-10-23
$47.00/1mg
VIP5Y
TargetMol Chemicals Inc.
2024-11-19
$20.00/25Kg/Drum
Wuhan Mulei New Material Technology Co. Ltd
2021-04-02
$0.00/1mg
VIP1Y
Hubei Chuchang Biotech Co., Ltd.
2024-03-28
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
INQUIRY