Mexiletine hydrochloride NEW
| Price | $35 | $48 | $68 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Mexiletine hydrochloride | CAS No.: 5370-01-4 |
| Purity: 98.44% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Mexiletine hydrochloride |
| Description | Mexiletine hydrochloride (KOE-1173 hydrochloride) is a voltage-gated sodium channel blocker and a Class IB antiarrhythmic drug. Mexiletine hydrochloride exerts antiarrhythmic effects by inhibiting sodium current in myocardial cells, thereby reducing the rise rate of cardiac action potential (phase 0) and reducing the automaticity of Purkinje fibers. |
| In vitro | Mexiletine shortened the cardiac Purkinje fiber effective response period (ERP) less than the action potential duration (APD), resulting in higher ERP/APD ratios.Mexiletine had no significant effect on atrioventricular conduction velocity, resting membrane potential, sinus node autoregulation, systolic arterial pressure, left ventricular function, or QRS or QT intervals. Mexiletine inhibits the inward flow of sodium ions through inhibition of sodium channels (requiring pulse initiation and conduction), which in turn reduces the rate of action potential elevation. |
| In vivo | Mexiletine shortened the cardiac Purkinje fiber effective response period (ERP) less than the action potential duration (APD), resulting in higher ERP/APD ratios.Mexiletine had no significant effect on atrioventricular conduction velocity, resting membrane potential, sinus node autoregulation, systolic arterial pressure, left ventricular function, or QRS or QT intervals. Mexiletine inhibits the inward flow of sodium ions through inhibition of sodium channels (requiring pulse initiation and conduction), which in turn reduces the rate of action potential elevation. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (231.78 mM) H2O : 21.6 mg/mL (100 mM) |
| Keywords | Na channels | KO-1173 | KOE 1173 | Sodium Channel | KOE-1173 | antiarrhythmic | Mexiletine | Inhibitor | KOE1173 | Mexiletine hydrochloride | ischemia | Class IB | myocardial | inhibit | KO 1173 | Mexiletine Hydrochloride | Na+ channels |
| Inhibitors Related | Phenytoin sodium | Lidocaine hydrochloride | L-Aspartic aicd sodium |
| Related Compound Libraries | Bioactive Compound Library | Drug Repurposing Compound Library | Neuroprotective Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Ion Channel Targeted Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $48.00/100mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
| $0.00/1kg |
VIP4Y
|
Sinoway Industrial co., ltd.
|
2024-06-17 | |
| $0.00/20kg |
VIP4Y
|
WUHAN FORTUNA CHEMICAL CO., LTD
|
2022-10-10 | |
| $1.10/1g |
VIP4Y
|
Dideu Industries Group Limited
|
2021-08-11 | |
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-10 | ||
| $95.00/1KG |
Longyan Tianhua Biological Technology Co., Ltd
|
2020-11-17 | ||
| $1.00/1g |
VIP6Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2020-05-08 | |
| $1.00/1KG |
VIP6Y
|
Career Henan Chemical Co
|
2020-02-04 | |
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-09 | ||
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-06-26 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY