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Postion:Product Catalog >API>Antiparasitic drugs>Antiamoebic and anti-trichomoniasis drugs>Metronidazole
Metronidazole
  • Metronidazole

Metronidazole NEW

Price $46
Package 500mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Metronidazole CAS No.: 443-48-1
Purity: 99.98% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameMetronidazole
DescriptionMetronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.
In vitroMetronidazole is relatively inactive until it is metabolized within host or microbial cells. Metronidazole is activated when it receives an electron from ferredoxin or fla vodoxin that is reduced by POR in anaerobic or microaerophilic bacteria or luminal parasites. Metronidazole damages cells by forming protein and DNA adducts. [1] Metronidazole has activity against protozoans like Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis, for which the drug is first approved as an effective treatment. The activity of metronidazole against anaerobic bowel flora has been used for prophylaxis and treatment of patients with Crohn's disease who might develop an infectious complication. Metronidazole has played an important role in anaerobic-related infections. Metronidazole has notable effectiveness in treating anaerobic brain abscesses. [2] Metronidazole resistance tends to result from de novo mutation in the resident rdxA gene, rather than from lateral transfer of mutant rdxA (or other) genes from unrelated but Mtzr strains. Metronidazole partially inhibits growth stimulate forward mutation to rifampin resistance in rdxA(+) (Metronidazole(s)) and also in rdxA (Metronidazole(r)) H. pylori strains, and that expression of rdxA in Escherichia coli results in equivalent Mtz-induced mutation. [3] Metronidazole leads to apoptosis-like features in growing cultures of axenic B. hominis, including key morphological and biochemical features of programmed cell death (PCD), viz. nuclear condensation and nicked DNA in nucleus, reduced cytoplasmic volume, externalization of phosphatidylserine and maintenance of plasma membrane integrity with increasing permeability. [4]
In vivoMETHODS: To assay antimicrobial activity in vivo, Metronidazole (3-15 mg/kg) was administered once daily by gavage to M. tuberculosis Erdman-infected C57BL/6 mice. RESULTS: Metronidazole did not reduce the number of bacteria in the lungs of aerosolized infected mice during the active phase of the disease, during the control phase, or after long-term isoniazid treatment (Cornell model). Small but significant reductions were seen if Metronidazole treatment was given in the established chronic disease state 100 days after aerosol administration. [3]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationEthanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 60 mg/mL (350.55 mM)
H2O : 10 mg/mL (58.43 mM), Sonication is recommended.
10% DMSO+90% Saline : 3.2 mg/mL (18.7 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
KeywordsEntamoeba histolytica | Apoptosis | iNOS | Giardia lamblia | anaerobic protozoa | anaerobic infection | adiponectin | inhibit | Antibiotic | eNOS | Bacterial | Bcl2 | Cry2 | Parasite | Balantidium coli. | Ror-β | Inhibitor | Trichomonas vaginalis | Bax | E4BP4. PP ARγ | Metronidazole | caspase-3
Related Compound LibrariesAnti-Parasitic Compound Library | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Microbial Natural Product Library | FDA-Approved Drug Library | Anti-infective Natural Product Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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