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Postion:Product Catalog >API>Antibiotics>Tetracycline drugs>Methacycline hydrochloride
Methacycline hydrochloride
  • Methacycline hydrochloride

Methacycline hydrochloride NEW

Price $52 $81
Package 100mg 200mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-18

Product Details

Product Name: Methacycline hydrochloride CAS No.: 3963-95-9
Purity: ≥98% Supply Ability: 10g
Release date: 2024/11/18

Product Introduction

Bioactivity

名稱Methacycline hydrochloride
描述Methacycline hydrochloride (Rondomycin) is a broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period.
體外活性Methacycline, within pulmonary alveolar macrophages, does not alter the response gene of TGF-β1 nor attenuates the aggregation of inflammatory cells. Following tracheal aspiration of bleomycin, intraperitoneal injection of Methacycline at 100 mg/kg, starting on day 10, enhances survival rates by day 17. Methacycline mitigates bleomycin-induced classical EMT (Epithelial-Mesenchymal Transition) markers, including SNAIL1, TWIST1, type I collagen, fibronectin, and their mRNA expressions.
體內(nèi)活性Methacycline inhibits the TGF-β1-induced non-Smad signaling pathways, including the activation of c-Jun N-terminal kinase (JNK), p38, and Akt, without suppressing Smad or β-catenin transcriptional activities. It does not affect the baseline activities of JNK, p38, or Akt, nor the TGF-β1 response of lung fibroblasts. Additionally, methacycline inhibits the TGF-β1-induced expression of α-smooth muscle actin (α-SMA), SNAIL1, and type I collagen in primary alveolar epithelial cells.
存儲條件keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 27.5 mg/mL (57.43 mM)
關(guān)鍵字fibrosis | fibrogenesis | c-Jun | TGF-β1 | Methacycline | N-terminal | Inhibitor | p38 | inhibit | Methacycline hydrochloride | Bacterial | epithelial-mesenchymal | Antibiotic | kinase | Smad | transition | EMT | pulmonary | Methacycline Hydrochloride | Akt
相關(guān)產(chǎn)品Neomycin sulfate | Dimethyl sulfoxide
相關(guān)庫FDA上市及藥典收錄分子庫 | 經(jīng)典已知活性庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 微生物天然產(chǎn)物庫 | FDA 上市藥物庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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