天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
+1 (818) 612-2111
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >API>Mertansine
Mertansine
  • Mertansine

Mertansine NEW

Price $30 $64 $98
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-08

Product Details

Product Name: Mertansine CAS No.: 139504-50-0
Purity: 99.76% Supply Ability: 10g
Release date: 2024/11/08

Product Introduction

Bioactivity

名稱Mertansine
描述Mertansine is a tubulin inhibitor and an antibody-conjugable maytansinoid alkaloid. The IC50 of Mertansine against HCT-15 and A431 cells is 0.750 and 0.04nM.
體外活性METHODS: HCT-15 and A431 cells were incubated with Mertansine (0-3 nM) for 72 hours, then the medium was removed from the plate and replaced with fresh medium. Allow the culture to grow and form colonies for 7-10 days after plating. Cultures were fixed, stained with 0.2% crystal violet in 10% formalin/PBS, and colonies were counted. RESULTS Mertansine can inhibit the growth of HCT-15 and A431 cells. [1] METHODS: 4T1 cells were incubated with Mertansine (5-100 μg/mL) for 4 hours, and cell viability was detected by CCk8. RESULTS Mertansine can inhibit the growth of 4T1 cells.[2] METHODS: MDA-MB-231 cells were incubated with Mertansine (0.001355–13.55μM) for 48 hours, and cancer cell viability was detected by MTT. RESULTS Mertansine can effectively inhibit the proliferation of MDA-MB-231 cells, with an IC50 value of 0.12 μM. [3]
體內(nèi)活性METHODS: The anti-tumor activity of Mertansine (0.5 mg/kg) was evaluated in mice with orthotopic 4T1 tumors. RESULTS Cancer cell apoptosis was significantly increased, and the effect was dose-dependent. [2] METHODS: The in vivo therapeutic properties of Mertansine were evaluated using MDA-MB-231 triple-negative breast tumor mice. Mertansine was administered every 3 days for a total of four injections at a dose of 0.8 mg/kg. RESULTS Mertansine demonstrated modest inhibition of cancer cell growth in MDA-MB-231 triple-negative mammary tumor mice.[3]
存儲條件store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice.
溶解度DMSO : 83.33 mg/mL (112.87 mM), The compound is unstable in solution, please use soon.
H2O : < 0.1 mg/mL (insoluble)
關(guān)鍵字Maytansinoid DM-1 | Maytansinoid DM 1 | melanoma | Inhibitor | B16F10 | ADC Payload | ADC Cytotoxin | DM-1 | DM 1 | tubulin | Microtubule/Tubulin | antiproliferative | inhibit | mitosis | Mertansine | antitumor | ADC
相關(guān)產(chǎn)品Dexamethasone acetate | Methylene Blue trihydrate

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$30.00/10BOX
Shanghai Chinqesen Biotechnology Co., Ltd.
2023-11-01
$1.10/1g
VIP4Y
Dideu Industries Group Limited
2021-08-18
$15.00/1KG
Zhuozhou Wenxi import and Export Co., Ltd
2021-07-11
$10.00/1KG
Wuhan Monad Medicine Tech Co.,LTD
2020-12-22
$1.00/1BOU/Drum
HONG KONG IPURE BIOLOGY CO.,LIMITED
2020-11-24
$40.00/1KG
Longyan Tianhua Biological Technology Co., Ltd
2020-10-27
$1500.00/200KG
VIP7Y
Career Henan Chemical Co
2018-08-04
$10.00/5mg
Longyan Tianhua Biological Technology Co., Ltd
2020-10-23
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
INQUIRY