Product Details
| Product Name:
Mefentrifluconazole |
CAS No.:
1417782-03-6 |
| Purity:
99.88% |
Supply Ability:
10g |
| Release date:
2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | Mefentrifluconazole |
| 描述 | Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM). Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent. |
| 體內(nèi)活性 | In the acute and repeat dose toxicity studies performed with Mefentrifluconazole.?A single-dose administration to rats the LD50 is >2000?mg/kg bwt by the oral route, >5000?mg/kg bwt by the dermal route, and >5.314?mg/L by inhalation as a dust aerosol.?Mefentrifluconazole is not a skin or an eye irritant, nor is it a phototoxicant in vitro.In the acute neurotoxicity study in rats, Mefentrifluconazole (oral administration;?2000?mg/kg bwt;?single dose) gives rise to reduce body weight gain and transient neurobehavioral effects only on the day of treatment (unsteady gait, reduced motor activity, reduces grip strength of the forelimbs and increased distance between the hind limbs in the landing foot-splay test).In the repeated-dose toxicity studies, the liver is the target organ in each of the three species investigated.?At higher dose levels in the rat (oral diets;?383/334 mg/kg/bwt/d (4000 ppm)) and the C57BL/6JRj mouse (61 mg/kg bwt/d (300 ppm)), reduces body weight gain and food consumption, alters clinical chemistry parameters, increases liver weight and is accompanied by liver cell hypertrophy, and/or liver cell necrosis.?At low doses, increases liver weight is not associated with any histopathological alterations and is considered to be an adaptive change to treatment. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 100 mg/mL (251.40 mM), Sonication is recommended.
|
| 關(guān)鍵字 | CYPs | aromatase | Inhibitor | antifungal | Fungal | derivative | cell | azole | Mefentrifluconazole | hypertrophy | liver | necrosis | Cytochrome P450 | irritant | inhibit |
| 相關(guān)產(chǎn)品 | Dehydroacetic acid sodium | 2-Butyl-1,2-benzisothiazolin-3-one | Tebuconazole | Veratraldehyde | Paclobutrazol | Lauryl betaine | Geraniol | Naringin | Naringenin |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 抗真菌庫(kù) | 抑制劑庫(kù) | NO PAINS 化合物庫(kù) | 代謝化合物庫(kù) | 口服活性化合物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 抗癌化合物庫(kù) | 抗感染化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$84.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-18 |
United States