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Postion:Product Catalog >MCT1-IN-3
MCT1-IN-3
  • MCT1-IN-3

MCT1-IN-3 NEW

Price $117 $268 $395
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-15

Product Details

Product Name: MCT1-IN-3 CAS No.: 2878360-80-4
Purity: 98.87% Supply Ability: 10g
Release date: 2024/11/15

Product Introduction

Bioactivity

名稱MCT1-IN-3
描述MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor, targeting solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) for cancer treatment. MCT1-IN-3 (compound 24) showed the highest MCT1 transport inhibition with an IC50 value of 81.0 Nm and also exhibits significant inhibitory activity against the multidrug transporter ABCB1.
體外活性MCT1-IN-3 has great antiproliferative activities against the MCT1-expressing cancer cell lines A-549 and MCF-7 with GI50 values of 20 μM and 15.1 μM, respectively. Treatment with MCT1-IN-3 5μM for 24 h significantly leads to cancer cell cycle arrest as well as apoptosis, which has also significant inhibitory power against the multidrug transporter ABCB1 and shows to reverse ABCB1-mediated multidrug resistance (MDR)[1].
存儲條件Shipping with blue ice.
溶解度DMSO : 22.5 mg/mL (57.78 mM)
關(guān)鍵字MCT1-IN-3 | MCT1IN3
相關(guān)產(chǎn)品7ACC1 | BAY-8002 | AZD0095 | Niflumic acid | D-Phenylalanine | AZD3965 | α-Cyano-4-hydroxycinnamic acid | MSC-4381 | 7ACC2 | AR-C155858 | Coumarin343 | VB124
相關(guān)庫經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 抑制劑庫 | 已知活性化合物庫 | 抗癌化合物庫 | 抗癌活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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