Magnesium Lithospermate B NEW
| Price | $115 | $247 | $368 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: Magnesium Lithospermate B | CAS No.: 122021-74-3 |
| Purity: 99.87% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | Magnesium Lithospermate B |
| 描述 | Magnesium Lithospermate B is a natural product activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from ischemic injury through specific inhibition of TAB1-p38 apoptosis signaling.improves renal failure. |
| 動(dòng)物實(shí)驗(yàn) | Adult male Sprague-Dawley rats were subjected to an endovascular perforation process to produce an SAH model.?MLB was administrated intraperitoneally at 30min after SAH with a dose of 25mg/kg or 50mg/kg[1]. |
| 體外活性 | magnesium lithospermate B (MLB) dose-dependently inhibited the activation of microglia and reduced neuronal apoptosis.?Western blot analysis showed that MLB decreased the expression of inflammatory cytokine TNF- and pro-apoptotic protein cleaved caspase-3.?More importantly, MLB increased the expression of SIRT1, while inhibited the acetylation of NF-B.?Furthermore, pretreatment with sirtinol (a selective inhibitor of SIRT1) reversed all the aforementioned effects of MLB after SAH[1]. |
| 體內(nèi)活性 | magnesium lithospermate B (MLB), a bioactive ingredient extracted from Salvia miltiorrhiza, exerts neuroprotective effects in several central nervous system insults.administration of MLB significantly attenuated brain edema and neurological deficits after SAH[1]. |
| 存儲(chǔ)條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 7.41 mg/mL (10 mM) |
| 關(guān)鍵字 | tetramer | oxidative | cardiovascular | Salviae | neuroin?ammation | miltiorrhizae | inhibit | acid | Magnesium Lithospermate B | diseases | caffeic | Inhibitor | damage |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 中藥單體化合物庫 | 植物來源化合物庫 | 中藥抗炎分子庫 | 天然產(chǎn)物庫 | 高通量篩選天然產(chǎn)物庫 | 化妝品成分化合物庫 | 已知活性化合物庫 | 古代經(jīng)典名方目錄分子庫 | 藥食同源庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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