M62812 free base NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: M62812 free base | CAS No.: 613262-61-6 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | M62812 free base |
| Description | M62812 (free base), a Toll-like receptor 4 (TLR4) signal transduction inhibitor, suppresses activation of endothelial cells and leukocytes and prevents lethal septic shock in mice. It is utilized in sepsis research [1]. |
| In vitro | M62812 (0-10 μg/ml) suppresses the LPS-induced upregulation of inflammatory cytokines, adhesion molecules, and procoagulant activity in human endothelial cells and peripheral mononuclear cells [1]. |
| In vivo | M62812, administered intravenously at dosages of 10-20 mg/kg as a single injection, protected mice from lethality in a d-galactosamine-sensitized endotoxin shock model, also reducing inflammatory and coagulation parameters [1]. Moreover, a daily dose of 20 mg/kg of M62812 prevented mortality in mice subjected to a cecal ligation and puncture model [1]. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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