Losartan potassium NEW
| Price | $33 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Losartan potassium | CAS No.: 124750-99-8 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Losartan potassium |
| Description | Losartan potassium (DuP-753 potassium), an Angiotensin II Receptor Blocker, selectively and competitively inhibits the binding of angiotensin II to the angiotensin I (AT1) receptor. |
| Cell Research | An MTT assay is used to measure cell proliferation and viability. For the assay, 5000 cells in 200?μL media per well are seeded in a 96 well plate. After overnight incubation to allow for cell attachment, the medium is removed by suction. MTT at 1?mg/mL concentration in serum-free medium is added and then incubated for 4?h at 37°C. After removal of MTT solution, 100?μL of DMSO is added to dissolve formazan crystals. Absorbance at 570?nm and at 600?nm as a reference is then measured using a microplate reader. The difference in absorbance is thus relative to the extent of cell survival. |
| In vitro | Losartan competes with the binding of angiotensin II to AT1 receptors, with an IC50 of 20 nM[1]. At 40 μM, losartan affects ISC and prevents the effect of ANGII on ISC[2]. It significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells, and in combination with anti-miR-155, it exhibits a significantly greater antiproliferative effect compared to each drug alone[3]. |
| Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 46.1 mg/mL (100 mM) DMSO : 55 mg/mL (119.3 mM) |
| Keywords | Angiotensin Receptor | MK954 | inhibit | Losartan | Losartan potassium | DuP-753 | DuP753 | MK-954 | Inhibitor |
| Inhibitors Related | Tranilast | Enalapril Maleate | Azilsartan Methyl Ester | Sacubitril/Valsartan | Azilsartan | Irbesartan | Losartan | Ramipril | Captopril | Valsartan Methyl Ester |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Angiogenesis related Compound Library | Inhibitor Library | Endocrinology-Hormone Compound Library | FDA-Approved Drug Library | Orally Active Compound Library | Bioactive Compounds Library Max | Anti-Hypertension Compound Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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