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Postion:Product Catalog >API>Circulatory system drugs>Antihypertensive drugs>Lisinopril Dihydrate
Lisinopril Dihydrate
  • Lisinopril Dihydrate
  • Lisinopril Dihydrate

Lisinopril Dihydrate NEW

Price Get Latest Price
Package 1kg
Min. Order: 1kg
Supply Ability: 20tons
Update Time: 2024-04-08

Product Details

Product Name: Lisinopril Dihydrate CAS No.: 83915-83-7
EC-No.: 627-033-9 Min. Order: 1kg
Purity: 99% Supply Ability: 20tons
Release date: 2024/04/08

Lisinopril is a third-generation angiotensin-converting enzyme inhibitor and a lysine derivative of enalapril. It was marketed in the United States in 1987 for the treatment of hypertension and is a first-line antihypertensive drug . The pharmacological action characteristics are similar to Enalapril (Enalapril), with strong angiotensin-converting enzyme inhibitory effect, quick onset and long action time, just take the medicine once a day. The inhibitory effect on ACE is 6 to 8 times that of captopril and 1 to 3 times that of benazepril.
Function and Application 

Angiotensin Converting Enzyme Inhibitor (ACE-I), a lysine derivative of Enalapril, is the third non-sulfhydryl group in the world to be marketed. ACE-I. Long-acting, once a day, and the dosage is only 1/20 of captopril, 1/4 of enalapril, oral bioavailability is better. The curative effect is remarkable. For moderate and severe patients, the Chemicalbook should be better than captopril and enalapril. It has no direct effect on the heart, does not cause arrhythmia, has no central effect, and has no adverse reactions such as blood pressure rebound. It can be used for diseases accompanied by diabetes, asthma, peripheral vascular disease, psychosis and congestive heart failure, and for other diseases Patients with hypertension who are contraindicated in the treatment of drugs. It is effective for short-term and long-term congestive heart failure.

Product NameLisinopril dlhydrate
ReferenceUSP
TestSpecificationResults
CharactersWhite crystalline powder.White crystalline powder.
Identification1) Infrared absorption spectrum concordant with spectrum obtained with Lisinopril dihydrate RS.Conform
2) The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that of the Standard preparation obtained as directed in the Assay.Conform
Specific optical rotation [a]Hg25-115.3-122.5°-119.6°
Water8.0~9.5%8.3%
Residue on ignition≤0.1%<0.1%
Assay (HPLC)98.0-102.0% (calculated on anhydrous basis)98.6%
Residual solventsEthanol≤0.5%0.017%
Related substances (HPLC)DL-Homophenylalanine ≤0.30%<RL(RL:0.05%)
Related compound A ≤0.3%<RL(RL:0.05%)
R,S,S-Diketopiperazine ≤0.3%<LOD(LOD:0.01%)
Lisinopril epimer ≤0.3%0.07%
Lisinopril cyclohexyl analogue ≤0.30%0.08%
N-Alkyl-L-lysine ≤0.3%0.09%
N-Alkyl lisinopril ≤0.15%<LOD(LOD:0.01%)
Any individual unspecified impurity≤0.10%<RL(RL:0.05%)
Total imp. does not include lisinopril epimer≤0.5%0.17%
ConclusionComplies with USP

 Article illustration

Company Profile Introduction

Shaanxi TNJONE Pharmaceutical Co., Ltd supplies more than 2,000 kinds of products, covering the whole field of health industry, including human APIs, veterinary APIs, food additives, natural nutrition ingredients, feed additives, cosmetic additives, intermediates etc. With global sourcing advantages, the group is fully capable of meeting the one-stop sourcing needs of global customers. Today, Shaanxi TNJONE Pharmaceutical Co., Ltd.'s marketing network has spread over more than 100 countries and regions on five continents, providing professional service for global customers.

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Shaanxi TNJONE Pharmaceutical Co., Ltd

1YR ChinaChina
  • Since: 2019-05-23
  • Address: No. 4C-11-A392, Financial Port, Northwest corner of Fengjing Avenue and Fengxin Road, Fengdong New C
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