Liothyronine NEW
| Price | $36 | $50 | $71 |
| Package | 50mg | 100mg | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Liothyronine | CAS No.: 6893-02-3 |
| Purity: 99.28% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Liothyronine |
| Description | Liothyronine (Tresitope) is an active form of thyroid hormone, binding to β1 thyroid hormone receptor (TRβ1), and activates its activity. |
| In vitro | METHODS: Mouse colon adenocarcinoma cells MC38 were treated with Liothyronine (12.5-100 μM) for 24-72 h. Cell viability was measured using MTT Assay. RESULTS: Liothyronine did not affect the cell viability of MC38 cells at the concentrations tested. [1] METHODS: Jurkat hTIGIT cells were stimulated with anti-CD3 and anti-CD28 stimulatory antibodies and treated with anti-TIGIT (1 μg/mL) and Liothyronine (100 μM) for 48 h. The frequency of IL-2 secreting Jurkat hTIGIT was detected using Flow cytometry. RESULTS: TIGIT/PVR interaction significantly inhibited IL-2 secretion from Jurkat hTIGIT cells, and the inhibition was significantly reversed by a functional anti-TIGIT antibody and Liothyronine, which has the typical characteristics of an immune checkpoint blocker. [1] |
| In vivo | METHODS: To detect anti-tumor activity in vivo, Liothyronine (1.5-5 mg/kg, normal saline with 3% DMSO and 0.5% Tween-80) was injected intraperitoneally every two days for two weeks into C57BL/6 mice bearing MC38 tumors. RESULTS: Both low and high doses of Liothyronine significantly inhibited the growth of MC38 tumors. Liothyronine significantly increased the frequency of tumor-infiltrating CD8+ T cells and significantly enhanced the secretion of IFN-γ by tumor-infiltrating CD4+ T cells treated with high doses of Liothyronine. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4.95 mg/mL (7.6 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO : 1 mg/mL, Sonication is recommended. |
| Keywords | Inhibitor | Endogenous Metabolite | Liothyronine | Thyroid Hormone Receptor | inhibit | TRα | T-3 | T 3 | thyroid hormone | THR | TRβ |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Natural Product Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Human Endogenous Metabolite Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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