Latrunculin B NEW
| Price | $998 |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-30 |
Product Details
| Product Name: Latrunculin B | CAS No.: 76343-94-7 |
| Supply Ability: 10g | Release date: 2025/04/30 |
Product Introduction
Bioactivity
| Name | Latrunculin B |
| Description | Latrunculin B, an alkaloid from the Red Sea sponge, is an actin polymerization inhibitor with antifungal and antiprotozoal activity.Latrunculin B modulates the electrophysiological characteristics of the pulmonary veins and attenuates the occurrence of torsade de pointes, and may be used in the study of glaucoma in adolescents. |
| In vitro | Displaying growth inhibition of HeLa cells with an IC50 value of 1.4 μM, Latrunculin B also modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes[1]. In pulmonary vein (PV) preparations, Latrunculin B (100 nM) decreases spontaneous electrical activity by 16±4%. Moreover, it reduces the late Na+ current, L-type Ca2+ current, Na+/Ca2+ exchanger current, and stretch-activated BKCa current in PV cardiomyocytes. Latrunculin B alters the transient outward K+ current and ultra-rapid delayed rectifier K+ current, while increasing the delayed rectifier K+ current in isolated PV cardiomyocytes. Additionally, at a concentration of 100 nM, Latrunculin B decreases intracellular Ca2+ transient and sarcoplasmic reticulum Ca2+ content in PV cardiomyocytes, attenuating stretch-induced increased spontaneous electrical activity and trigger activity[2]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : Soluble |
| Keywords | Latrunculin B | INS-115644 | INS 115644 | Fungal |
| Inhibitors Related | Dehydroacetic acid sodium | Chlorobutanol hemihydrate | 2-Butyl-1,2-benzisothiazolin-3-one | Tebuconazole | Potassium gluconate | Chitosan (MW 150000) | Methyl 2-amino-5-bromobenzoate | Veratraldehyde | Paclobutrazol | Lauryl betaine | Geraniol | Sorbic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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