Laminaran NEW
| Price | $39 | $91 |
| Package | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: Laminaran | CAS No.: 9008-22-4 |
| Purity: 98% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | Laminaran |
| 描述 | Laminaran is a β-1,3-glucan isolated from brown algae, often serving as a typical ligand for Dectin-1. It possesses anti-cancer, immune-modulating, and radiation-protective properties. Laminaran can be catalyzed by glucanase. In in vitro and in vivo experiments, Laminaran has demonstrated anti-tumor activity and may be used for severe cancers. |
| 體外活性 | Laminaran ( 100-800μg / mL ; 24 h ) had no cytotoxicity to normal epidermal cells JB6 Cl41 and human melanoma cells SK-MEL-28. After 15 hours of treatment, the inhibition percentage of the number of living cells was less than 24 % when the concentration was up to 800μg / mL [ 1 ]. Kelp glycan ( 200μg / mL ; 24-72 hours ) did not induce any growth inhibition of SK-MEL-48 cells after treatment for 28 hours and 24 hours. However, it reduced cell proliferation by 72 % after 36 hours of treatment [ 1 ]. Low concentration of kelp glycan ( 25-50μg / mL ; 24 h ) did not affect the phosphorylation of c-Raf ( Ser259 ), ERK1 / 2 ( Tyr202 / Tyr204 ) and MEK1 / 2 ( Ser 221 ) kinases, as well as the total expression level of the studied proteins. However, it reduced p-MEK and p-ERK2 / 50 at 1 μg / mL [ 1 ]. |
| 體內(nèi)活性 | Compared with PBS-, OVA-and kelp protein-treated mice, Laminaran ( intravenous injection ; 12.5,25 and 50 mg / kg ; 21 days ) and OVA ( 50μg ) combination significantly reduced tumor mass [ 2 ]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 20 mg/mL (38.35 mM), Sonication is recommended. DMSO : < 1 mg/mL (insoluble）, Sonication is recommended. |
| 關(guān)鍵字 | Laminaran | b-1,3-Glucan | beta-1,3-Glucan |
| 相關(guān)庫 | 抗癌天然產(chǎn)物庫 | 中藥單體化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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