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Postion:Product Catalog >L-BUTHIONINE-(S,R)-SULFOXIMINE
L-BUTHIONINE-(S,R)-SULFOXIMINE
  • L-BUTHIONINE-(S,R)-SULFOXIMINE

L-BUTHIONINE-(S,R)-SULFOXIMINE NEW

Price $33 $47 $80
Package 25mg 50mg 100mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: L-BUTHIONINE-(S,R)-SULFOXIMINE CAS No.: 83730-53-4
Purity: ≥98% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameL-BUTHIONINE-(S,R)-SULFOXIMINE
DescriptionL-Buthionine-(S,R)-sulfoximine, a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM), induces oxidative stress in cells by depleting GSH.
In vitroIC50 values (microM) for L-buthionine-S,R-sulfoximine (BSO) on melanoma, breast and ovarian tumor specimens were 1.9, 8.6, and 29, respectively. The IC90 for melanoma was 25.5 microM, a level 20-fold lower than steady-state levels achieved clinically [1]. GSH loss induced by L-buthionine-S,R-sulfoximine (BSO) leads to overproduction of reactive oxygen species (ROS) and triggers apoptosis of MYCN-amplified neuroblastoma cells [2].
In vivoSystemic BSO administration selectively altered GSH homeostasis and EAAT3 levels in the mice cerebellum. Intraperitoneal treatment of mice with 6?mmol/kg of BSO depleted GSH and GSSG in the liver at 2?h of treatment [3].
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : Insoluble
H2O : 50 mg/mL (224.91 mM), Sonication is recommended.
KeywordsFerroptosis | stress | GSH | Inhibitor | eye-spot | inhibit | oxidative | L-BUTHIONINE-SULFOXIMINE | glutamylcysteine | LBUTHIONINE(S,R)SULFOXIMINE | L BUTHIONINE (S,R) SULFOXIMINE | L-BSO | L-Buthionine sulfoximine | BSO
Inhibitors RelatedCurcumin | L-Cystine
Related Compound LibrariesBioactive Compound Library | HIF-1 Signaling Pathway Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Cell Cycle Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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