KPT185 NEW
| Price | $30 |
| Package | 2mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: KPT185 | CAS No.: 1333151-73-7 |
| Purity: 98% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | KPT185 |
| Description | KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest. |
| Cell Research | Cells are seeded into 96-well plates and treated for 24, 48, and 72 hours with KPT-SINE at various concentrations ranging from 10 nM to 10 μM. Cell viability is evaluated using the cell proliferation reagent WST-1 according to the manufacturer's protocol. The absorbance of wells at 450 nm (reference wavelength, 650 nm) is measured with a microplate reader. (Only for Reference) |
| In vivo | In leukemia cells (IC50=100 nM-500 nM), KPT-185 significantly inhibited cell proliferation. In AML cell lines and primary AML mother cells, KPT-185 was able to arrest the cell cycle and induce apoptosis. In pancreatic cancer cells, KPT-185 inhibited cell proliferation and induced apoptosis, but KPT-185 did not affect the growth of human pancreatic ductal epithelial cells. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : <1 mg/mL DMSO : 66 mg/mL (185.8 mM) Ethanol : 66 mg/mL (185.8 mM) |
| Keywords | KPT185 |
| Inhibitors Related | Selinexor (KPT-330) | Leptomycin B | Leptomycin A | CRM1-IN-2 | (E)-KPT330 | Verdinexor | LFS-1107 | KPT276 | CBS9106 | CRM1-IN-1 |
| Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Preclinical Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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