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Postion:Product Catalog >KB-5492 free base
KB-5492 free base
  • KB-5492 free base

KB-5492 free base NEW

Price $35 $56 $79
Package 2mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-20

Product Details

Product Name: KB-5492 free base CAS No.: 113594-64-2
Purity: 99.07% Supply Ability: 10g
Release date: 2024/11/20

Product Introduction

Bioactivity

NameKB-5492 free base
DescriptionKB-5492 free base is an orally available and selective antiulcer agent that inhibits sigma receptors, inhibits [3H]1,3-di(2-tolyl)guanidine (DTG) binding to sigma receptors, and may be useful in the study of gastric lesions and gastric secretion.
In vitroKB-5492 free base selectively inhibited specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor (IC50 = 3.15 microM) with a pseudo-Hill coefficient of 0.33[1].
In vivoIn male Sprague-Dawley rats weighing 210-240 g, induction of gastric mucosal damage was reduced by KB-5492 free base (200 mg/kg; oral gavage) compared to the control group. Additionally, it prevented deep mucosal lesions and exfoliation of surface epithelial cells[2].
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 80 mg/mL (185.83 mM), Sonication is recommended.
Inhibitors RelatedCutamesine dihydrochloride | Blarcamesine hydrochloride | Amitriptyline hydrochloride | S1R agonist 2 | Ditolylguanidine | 4-PPBP maleate | Sigma-1 receptor antagonist 1 | Glycerol phenylbutyrate | KSK67 | AB21 HCl
Related Compound LibrariesBioactive Compound Library | Bioactive Compounds Library Max | GPCR Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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