Kartogenin NEW
| Price | $46 | $53 | $91 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: Kartogenin | CAS No.: 4727-31-5 |
| Purity: 97.79% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | Kartogenin |
| 描述 | Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. |
| 細(xì)胞實(shí)驗(yàn) | For the cell viability assay, fibroblasts are seeded on six-well plates, followed by Kartogenin or DMSO treatment. According to the manufacturer's instructions, cell viability and viability are assessed by AlamarBlue assay.(Only for Reference) |
| 體外活性 | Kartogenin promotes type I collagen synthesis in dermal fibroblasts by activating the Smad4/Smad5 pathway, without exhibiting significant cytotoxicity on the activity, morphology, and survival of fibroblasts. Additionally, by enhancing the nuclear localization of CBFβ, Kartogenin induces differentiation of hMSCs into chondrocytes and protects articular chondrocytes. |
| 體內(nèi)活性 | Kartogenin at a concentration of 100 nM stimulates collagen synthesis in the dermis of mice. Additionally, it promotes the growth of skeletal limbs and the development of synovial joints in mice. Concentrations of 10 μM and 100 μM Kartogenin respectively enhance cartilage repair in mouse models of osteoarthritis (OA) induced by collagenase VII and surgically. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : <1 mg/mL DMSO : 63 mg/mL (198.52 mM) Ethanol : 18 mg/mL (56.72 mM), Heating is recommended. |
| 關(guān)鍵字 | Inhibitor | TGF-beta/Smad | stem | Kartogenin | chondrocytes | human | differentiation | inhibit | mesenchymal | Transforming growth factor beta | cells | osteoarthritis |
| 相關(guān)產(chǎn)品 | Monocrotaline | SB-431542 | DMH-1 | RepSox | Chromenone 1 | LY-364947 | BMP signaling agonist sb4 | Pirfenidone | A 83-01 | Galunisertib | Alantolactone | Pentabromophenol |
| 相關(guān)庫(kù) | 細(xì)胞重編程化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 細(xì)胞因子抑制劑庫(kù) | HIF-1化合物庫(kù) | 血管生成庫(kù) | 干細(xì)胞分化化合物庫(kù) | NO PAINS 化合物庫(kù) | 已知活性化合物庫(kù) | 抗肝癌化合物庫(kù) | 轉(zhuǎn)錄因子庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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