Product Details
Product Name:
JR14a |
CAS No.:
2411440-41-8 |
Purity:
99.29% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | JR14a |
Description | JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor. |
In vitro | In vitro, thiophene compounds potently inhibited intracellular Ca2+ release in human macrophages without
inhibiting the agonist effects in the same concentration range as the related Complement protein C5a[1]. |
In vivo | JR14a reduces mast cell degranulation and macrophage infiltration in BR103-induced rat paw edema[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 90 mg/mL (168.71 mM), Sonication is recommended.
|
Keywords | inflammation | Inhibitor | inhibit | C3a | JR-14a | Complement System | JR14a | complement |
Inhibitors Related | EG01377 2HCl | Iptacopan hydrochloride | SB290157 trifluoroacetate | BCX 1470 hydrochloride | Complement C5-IN-1 | ADH-503 | CP-289 | Dexamethasone | CP-447697 | Complement factor D-IN-2 | Cyclosporin A | 3-Phenoxybenzaldehyde |
Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:2408839-73-4
$699.00 / 2mg
-
CAS:346692-04-4
$50.00 / 5mg
-
CAS:165800-04-4
$88.00 / 1mg
Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |