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Postion:Product Catalog >JNJ-67856633
JNJ-67856633
  • JNJ-67856633

JNJ-67856633 NEW

Price $48 $113 $189
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: JNJ-67856633 CAS No.: 2230273-76-2
Purity: 99.97% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameJNJ-67856633
DescriptionJNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease . JNJ-67856633 lead to tumor stasis in some cases.
In vitroJNJ-67856633 is effective and highly bioavailable in both mouse and rat tumors, and in some cases led to tumor stasis. JNJ-67856633 results in potent in vivo pharmacodynamic shutdown in CD79b- as well as CARD11-mutant ABC-DLBCL models as measured by serum IL10 or uncleaved BCL10 levels in tumors[1][3].
In vivoTreatment with JNJ-67856633 was observed to cause dose-dependent inhibition of Tregs (CD4+CD25+FoxP3+) generation following CD3/28 stimulation, suggesting a potential immune-modulatory role of MALT1 inhibition[3].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 125 mg/mL (267.48 mM), Sonication is recommended.
Keywordsinhibit | active | allosteric | orally | selective | mucosa associated lymphoid tissue lymphoma translocation gene 1 | Inhibitor | JNJ67856633 | JNJ-67856633 | MALT1 | potent | JNJ 67856633
Inhibitors RelatedMIR96-IN-1 | MLT-748 | MLT-943 | Mepazine | MALT1 inhibitor MI-2
Related Compound LibrariesBioactive Compound Library | Hematonosis Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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