JNJ-42153605 NEW
| Price | $29 | $44 | $74 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: JNJ-42153605 | CAS No.: 1254977-87-1 |
| Purity: 98.57% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | JNJ-42153605 |
| Description | JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM). |
| In vitro | JNJ-42153605 has been evaluated for its specificity to the mGlu2 receptor, demonstrating no agonist or antagonist effects on other mGlu receptor subtypes at concentrations up to 30 μM. Additionally, it shows high permeability without evidence of P-glycoprotein efflux. |
| In vivo | JNJ-42153605 demonstrates significant in vivo efficacy by suppressing REM sleep at a 3 mg/kg oral dose in rats, as observed in the sleep-wake EEG paradigm—a result attributed to mGlu2 mediation. Additionally, it mitigates PCP-induced hyperlocomotion in mice, indicating antipsychotic properties, with an effective dose (ED50) of 5.4 mg/kg subcutaneously. The compound is rapidly absorbed in the gastrointestinal tract, peaking at 0.5 hours post-administration. It exhibits moderate to high clearance rates in both rats and dogs (35 and 29 mL/min/kg, respectively), with relatively short elimination half-lives of 2.7 hours in rats and between 0.8 to 1.1 hours in dogs[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : Slightly soluble |
| Keywords | Inhibitor | Metabotropic glutamate receptors | JNJ 42153605 | JNJ-42153605 | inhibit | JNJ42153605 | mGluR |
| Inhibitors Related | IDRA-21 | Topiramate | Decanoic Acid | Urethane | L-Cysteic acid monohydrate | Evans blue | L-Glutamine | Direct Blue 1 | L-Glutamic acid monosodium salt | Piracetam | O-Phospho-L-serine | Memantine hydrochloride |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Glutamine Metabolism Compound Library | Neurotransmitter Receptor Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Fluorochemical Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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