JMV 2959 hydrochloride (925238-89-7 free base) NEW
| Price | $35 | $81 | $129 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: JMV 2959 hydrochloride (925238-89-7 free base) | CAS No.: 2448414-54-6 |
| Purity: 98.09% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | JMV 2959 hydrochloride (925238-89-7 free base) |
| Description | JMV 2959 hydrochloride (925238-89-7 free base) is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells. |
| In vitro | JMV 2959 does not induce any intracellular calcium mobilization by itself. The dissociation constant of the receptor/JMV 2959 complex is determined by the Schild method. This experiment reveals a dissociation constant Kb of 19±6 nM.JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM. |
| In vivo | Intraperitoneal (i.p.) administration of Ghrelin at doses of 0.033, 0.1, and 0.33 mg/kg does not significantly affect acoustic startle responses (ASR) or prepulse inhibition (PPI) in rats. Conversely, i.p. injection of JMV 2959 at 1, 3, and 6 mg/kg reduces ASR and enhances PPI in a dose-dependent manner. While JMV 2959 at a non-effective dose on its own prevents PPI deficits induced by Phencyclidine (PCP) at 2 mg/kg, pre-administration of the highest dose of Ghrelin does not alter PPI responses to a sub-threshold dose of PCP (0.75 mg/kg). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 250 mg/mL (458.65 mM), Sonication is recommended. |
| Keywords | JMV 2959 hydrochloride (925238897 free base) | 925238-89-7 free base | 925238-89-7 | JMV2959 Hydrochloride | JMV 2959 hydrochloride (925238 89 7 free base) | JMV 2959 Hydrochloride | JMV-2959 Hydrochloride |
| Inhibitors Related | Ibutamoren Mesylate | Capromorelin Tartrate | AnaMorelin hydrochloride | YIL 781 | Anamorelin | CJC-1295 acetate(863288-34-0 free base) | hGPR91 antagonist 1 | L-692429 | TC-G-1008 | NF-56-EJ40 hydrochloride | TM-N1324 | Cortistatin-8 acetate |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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