Product Details
Product Name:
JI069 |
CAS No.:
850019-35-1 |
Purity:
98.01% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | JI069 |
Description | JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1. |
In vitro | In HEK293T cells and primary T cells, JI069 (1-10 μM) suppressed STAT3 activation as efficiently as other STATs, including STAT1, STAT5, and STAT6. JI069 effectively suppressed Th1, Th2, and Th17 differentiation while strongly promoting Treg differentiation.[1] |
In vivo | JI069 (25mg/kg weight; i.p.; 6-week-old DBA/1J mice) suppressed symptoms of collagen-induced arthritis (CIA) model in mice and inhibited the cytokine production from T cells as well as the STAT3 phosphorylation of synovial cells.[1] |
Storage | store at low temperature | Shipping with blue ice. |
Solubility Information | DMSO : 25 mg/mL (64.56 mM)
|
Keywords | JI069 | JI 069 | JI-069 | WAY 354189 | WAY354189 |
Inhibitors Related | Delgocitinib | Ruxolitinib | Nifuroxazide | Balsalazide sodium hydrate | Tofacitinib Citrate | Fludarabine | Niclosamide | Ruxolitinib phosphate | CASIN | Diosgenin | Niclosamide olamine | Artesunate |
Related Compound Libraries | Bioactive Compound Library | Epigenetics Compound Library | Kinase Inhibitor Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
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$/ |
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Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |