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Postion:Product Catalog >Biochemical Engineering>Inhibitors>protein tyrosine kinase>Irbinitinib
Irbinitinib
  • Irbinitinib

Irbinitinib NEW

Price Get Latest Price
Package 1KG
Min. Order: 1KG
Supply Ability: 1000KGS
Update Time: 2024-08-15

Product Details

Product Name: Irbinitinib CAS No.: 937263-43-9
Min. Order: 1KG Purity: 98%
Supply Ability: 1000KGS Release date: 2024/08/15

Email: sales@anbuchem.com

Whatsapp:+8618638608485

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Irbinitinib Basic information

Product Name: Irbinitinib

Synonyms: ONT-380);N4-(4-([1;4,6-QuinazolinediaMine, N6-(4,5-dihydro-4,4-diMethyl-2-oxazolyl)-N4-[3-Methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-;N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine;Irbinitinib;Irbinitinib(ARRY380);Irbinitinib (ARRY-380,Tucatinib,ONT 380);IRBINITINIB (ARRY-380; ONT-380)

CAS: 937263-43-9

MF: C26H24N8O2

MW: 480.52

EINECS: 200-001-8

Product Categories: Inhibitors;API

Mol File: 937263-43-9.mol

Irbinitinib Structure

Irbinitinib Chemical Properties

density 1.41±0.1 g/cm3(Predicted)

storage temp. Store at -20°C

solubility DMF:1.0(Max Conc. mg/mL);2.08(Max Conc. mM)

DMSO:49.0(Max Conc. mg/mL);101.97(Max Conc. mM)

DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.69(Max Conc. mM)

form A crystalline solid

pka 6.61±0.70(Predicted)

InChIKey SDEAXTCZPQIFQM-UHFFFAOYSA-N

SMILES N1=C2C(C=C(NC3=NC(C)(C)CO3)C=C2)=C(NC2=CC=C(OC3C=CN4N=CN=C4C=3)C(C)=C2)N=C1

Safety Information

MSDS Information

Irbinitinib Usage And Synthesis

Description Irbinitinib is also known as ARRY-380 or Tucatinib. ARRY-380 is an orally inhibitor of human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. It selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation. Therefore, ARRY-380 may be an alternative treatmentmethod for the treatment of HER2+ cancers.

Uses N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine is a novel?diarylamine ErbB inhibitor.

References Lee, P., et al. "In Vivo Activity of ARRY-380, a Potent, Small Molecule Inhibitor of ErbB2 in Combination with Trastuzumab, Docetaxel or Bevacizumab." Cancer Research 69.24 Supplement(2009):5104-5104.

Moulder, S. L., et al. "Abstract A143: ARRY-380, a selective HER2 inhibitor: From drug design to clinical evaluation." Molecular Cancer Therapeutics 10.Supplement 1(2011):A143-A143.

Dinkel, Victoria, et al. "Abstract 852: ARRY-380, a potent, small molecule inhibitor of ErbB2, increases survival in intracranial ErbB2+ xenograft models in mice." Cancer Research 72.8 Supplement(2012).

Company Profile Introduction

Anbu Chem is a leading provider of fine chemical manufacturing services. Our highly qualified and experienced expert team has been providing quality products and services to pharmaceutical companies, research laboratories, and other industries worldwide for over ten years. We specialize in manufacturing of a wide range of fine chemicals and pharmaceutical intermediates, including active pharmaceutical ingredients (API), intermediates, and excipients. Our commitment to quality, along with our expertise in chemical engineering, has allowed us to develop and manufacture products using the latest technologies, processes, and techniques. At Anbu Chem, our customers can rely on us for the quality assurance and safety of their products. We take our commitment to quality seriously and strive to ensure that each batch of chemicals is manufactured to the highest standards.

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  • Since: 2019-12-09
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