IRAK4-IN-28 NEW
| Price | $1970 | $2580 | $3400 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: IRAK4-IN-28 | CAS No.: 2952532-92-0 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | IRAK4-IN-28 |
| Description | IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme. It is utilized for research purposes in the study of inflammation and autoimmune diseases [1]. |
| In vitro | IRAK4-IN-28 does not inhibit cytochrome P450 enzymes CYP1A2, CYP2D6, CYP3A4, and hERG, indicating favorable safety and 'drug-like' properties [1]. However, it inhibits CYP2C9 and CYP2C19 with IC50 values of 12 μM and 2.7 μM, respectively [1]. It also exhibits high plasma protein binding in humans and rats (99.8% and 97.2%, respectively) [1]. Furthermore, IRAK4-IN-28 (1 h) dose-dependently suppresses LPS-induced TNF-α and IL-6 expression at mRNA and protein levels [1]. |
| In vivo | IRAK4-IN-28 (compound 42) exhibits favorable pharmacokinetic data in a rat model, with an oral bioavailability utilization rate of 68% [1]. A single oral dose of IRAK4-IN-28 at 50 or 100 mg/ml significantly reduces LPS-induced TNF-α and IL-6 cytokine release in a mouse model [1]. |
| Storage | Shipping with blue ice. |
| Inhibitors Related | IRAK inhibitor 2 | IRAK inhibitor 1 | IRAK-1-4 Inhibitor I | IRAK4-IN-1 | IRAK-4 protein kinase inhibitor 2 | ANTHRAQUINONE-2-CARBOXYLIC ACID | Thalidomide 4-fluoride | GLPG2534 | Zabedosertib | Zimlovisertib | AS-2444697 | JH-X-119-01 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $58.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
| $633.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-10-23 | |
| $0.00/1Kg |
VIP1Y
|
airuikechemical co., ltd.
|
2024-04-03 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY