Product Details
| Product Name:
inS3-54A18 |
CAS No.:
328998-53-4 |
| Purity:
99.54% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | inS3-54A18 |
| Description | inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects. |
| In vitro | inS3-54A18 selectively impedes STAT3's interaction with its inherent target sequences and diminishes the expression of genes downstream of STAT3. It significantly reduces the wound healing capacity in A549 and MDA-MB-231 cells to 64% and 76% at a concentration of 5μM, and further decreases healing to 47% and 39%, respectively, at 10μM. Notably, inS3-54A18 does not interfere with either the basal or IL-6-stimulated activation of STAT3, but specifically inhibits the expression of a STAT3 target gene, survivin. |
| In vivo | inS3-54A18 (200 mg/kg, p.o.) inhibits tumor growth, metastasis, and STAT3 target gene expression in an A549 cell mouse xenograft model[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 150 mg/mL (401.25 mM)
|
| Keywords | Inhibitor | inS-3-54A18 | inS3 54A18 | inS3-54A18 | inS354A18 | inhibit | STAT |
| Inhibitors Related | Nifuroxazide | Balsalazide sodium hydrate | Fludarabine | Scutellarin | Niclosamide | 2-(1,8-naphthyridin-2-yl)phenol | CASIN | Diosgenin | Niclosamide olamine | Artesunate | Alantolactone | Stattic |
| Related Compound Libraries | Anti-Colorectal Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library | Anti-Cancer Metabolism Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Active Compound Library | Transcription Factor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States