INH6 NEW

Price	$42	$91	$148
Package	10mg	25mg	50mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-19

Product Details

Product Name: INH6	CAS No.: 1001753-24-7
Purity: 99.17%	Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

Name	INH6
Description	INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment.
Cell Research	Standard XTT assays with a four-day drug treatment procedure are performed to measure the dose-dependent cytotoxicity of INH analogs in cultured cells. Triplicate sets are measured and compiled for final data presentation. The assay is performed by using a commercial kit following the instructions. In principle, cells are plated on 96-well dishes one day before the drug treatment, followed by drug treatment on day 2 and XTT assay on day 5 after drug addition. The absorption at 595 nm is measured with a plate reader and converted to cell survival percentages in comparison to mock treated groups.(Only for Reference)
In vitro	INH6 effectively targets the Hec1/Nek2 complex for degradation, and shows potent cell killing activity with IC50 of 1.7, 2.1, 2.4, and 2.5 μM in MDA-MB231, MDA-MB468, HeLa and K562 cell lines. INH6 also triggers mitotic abnormalities in HeLa cells, and induces apoptosis. [1]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : 9 mg/mL (27.9 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 60 mg/mL (186.1 mM)
Keywords	Apoptosis \| INH6 \| Inhibitor \| INH 6 \| inhibit \| INH-6
Inhibitors Related	Stavudine \| 5-Fluorouracil \| Acetylcysteine \| Kaempferol \| Myricetin \| Sodium 4-phenylbutyrate \| L-Ascorbic acid \| Dextran sulfate sodium salt (MW 4500-5500) \| Metronidazole \| Sorafenib \| Tributyrin \| Lidocaine hydrochloride
Related Compound Libraries	Apoptosis Compound Library \| Bioactive Compound Library \| Microtubule-Targeted Compound Library \| Inhibitor Library \| NO PAINS Compound Library \| PPI Inhibitor Library \| Bioactive Compounds Library Max \| Cytoskeletal Signaling Pathway Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.