Indolicidin NEW
| Price | $153 | $412 | $598 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Indolicidin | CAS No.: 140896-21-5 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Indolicidin |
| Description | Indolicidin is comprised of 13 amino acids, 5 of which are tryptophan residues, and the carboxylterminal arginine is carboxamidated. Indolicidin has the highest tryptophan content of any known protein. |
| In vitro | Indolicidin, a powerful antimicrobial peptide extracted from bovine neutrophil cytoplasmic granules, comprises 13 amino acids, including a notably high tryptophan content, with five tryptophan residues, and features a carboxamidated carboxylterminal arginine. This peptide, recognized for having the highest tryptophan level among proteins, also acts as a tridecapeptide amide exhibiting bactericidal activities rivaling those of prominent defensins and bactenecins in vitro. Its mechanism includes binding to surface lipopolysaccharide with high affinity, facilitating the permeabilization of Escherichia coli's outer membrane via the self-promoted uptake pathway, as evidenced by its interaction with 1-N-phenylnapthylamine. Furthermore, methyl esterification at Indolicidin's carboxyl terminus amplifies its effectiveness against both Gram-negative and Gram-positive bacteria, attributed to enhanced lipopolysaccharide binding and outer membrane permeabilization in Gram-negative bacteria, and pinpointing the cytoplasmic membrane as its action site through membrane permeabilization indicators in Escherichia coli. |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 10 mM |
| Keywords | Bacterial | Inhibitor | inhibit | Indolicidin |
| Inhibitors Related | Neomycin sulfate | Sulfamethoxazole sodium | Dimethyl sulfoxide |
| Related Compound Libraries | Bioactive Compound Library | Peptide Compound Library | NO PAINS Compound Library | Anti-Bacterial Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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