Imeglimin hydrochloride NEW
| Price | $34 | $48 | $79 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: Imeglimin hydrochloride | CAS No.: 775351-61-6 |
| Purity: 99.98% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | Imeglimin hydrochloride |
| 描述 | Imeglimin hydrochloride (EMD 387008 hydrochloride） is an oral hypoglycemic agent. Imeglimin improves insulin sensitivity, inhibits the production of reactive oxygen species, increases mitochondrial DNA, and improves mitochondrial function. |
| 體外活性 | METHODS: HMEC-1 cells were cultured in complete MCDB medium with indicated concentrations of glucose for 48 h in the absence or presence of 1 μM CsA, 250 μM N-acetylcysteine ??(NAC), or 100 μM Imeglimin hydrochloride (EMD 387008 hydrochloride). Cytotoxicity was assessed by staining cells with Alexa Fluor-conjugated Annexin V and PI. RESULTS Imeglimin hydrochloride prevented hyperglycemia-induced endothelial cell death. [1] METHODS: HepG2 cells were treated with 1, 3, or 10 mM Imeglimin hydrochloride for 3 h and the resulting changes in basal oxygen consumption rate (OCR) and ATP production were observed. RESULTS Imeglimin hydrochloride inhibited basal OCR and ATP production as well as maximal mitochondrial respiration in a concentration-dependent manner. [2] |
| 體內(nèi)活性 | METHODS: Male C57BL/6J OlaHsd mice received imeglimin hydrochloride (EMD 387008 hydrochloride) (200 mg/kg b.i.d) by oral gavage during the last 6 weeks of HFHSD feeding to observe the antidiabetic effects of imeglimin. RESULTS Imeglimin hydrochloride significantly reduced blood glucose and restored normal glucose tolerance. [3] METHODS: C57BL/6J mice were maintained on a normal diet and a 12-h light/12-h dark cycle. At 8 weeks of age, male mice were deprived of food overnight, allowed to refeed for 5 h, and then injected intravenously with 250 mg/kg of imeglimin hydrochloride. Blood samples were collected from the tail vein 1 h after injection and blood glucose levels were measured using a glucometer. RESULTS Imeglimin hydrochloride significantly reduced blood glucose, while plasma insulin levels were not affected by imeglimin. [3] |
| 存儲條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 55 mg/mL (286.97 mM) |
| 關(guān)鍵字 | EMD387008 | inhibit | mitochondrial | lowering | insulin | Mitochondrial Metabolism | oral | Imeglimin hydrochloride | Imeglimin Hydrochloride | ROS | Imeglimin | Inhibitor | Reactive Oxygen Species | function | EMD-387008 | EMD387008 Hydrochloride | sensitivity | EMD 387008 | EMD 387008 Hydrochloride | EMD-387008 Hydrochloride | glucose |
| 相關(guān)產(chǎn)品 | Sodium Thiocyanate | Acetylcysteine | Rotenone | L-Ascorbic acid | α-Vitamin E | Ammonium sulfate | Glucosamine | D-(+)-Glucono-1,5-lactone | Tempol | Lycopene | Coenzyme Q10 | Naringenin |
| 相關(guān)庫 | 銅死亡化合物庫 | 細胞重編程化合物庫 | 糖代謝化合物庫 | 神經(jīng)退行性疾病化合物庫 | 抗乳腺癌化合物庫 | 細胞焦亡化合物庫 | NO PAINS 化合物庫 | 抗前列腺癌化合物庫 | 抗肝癌化合物庫 | 氧化還原化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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