Product Details
| Product Name:
Ifebemtinib |
CAS No.:
1227948-82-4 |
| Purity:
99.82% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Ifebemtinib |
| Description | Ifebemtinib (BI-853520) is an orally active and potent inhibitor of adhesion plaque kinase (FAK) (IC50=1 nM) with anti-tumour activity that inhibits globule formation and in situ tumour growth in malignant pleural mesotheliomas, and may be useful for the study of breast and ovarian cancer. |
| In vitro | 4T1, Py2T, and Py2T-LT cells were exposed to increasing concentrations of BI-853520 (0, 0.1, 0.5, 1, 5, and 10 μM for 4T1 cells; 1, 3, and 10 μM for Py2T and Py2T-LT cells) for 24 hours. The results demonstrate that BI-853520 reduces Y397-FAK phosphorylation in a dose-dependent and time-dependent manner[2]. |
| In vivo | In PC-3 cells, BI-853520（Ifebemtinib；0-3 μM; 2 h) resulted in a concentration-dependent reduction of the signal, with a median EC50 value of 1?nM[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (84.89 mM)
|
| Inhibitors Related | Chloropyramine hydrochloride | Roslin 2 bromide | PF-562271 | Ifebemtinib FA | Y15 | Defactinib | Masitinib | PF-573228 | Fangchinoline | FAK-IN-10 |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States