Product Details
| Product Name:
HSR6071 |
CAS No.:
111374-21-1 |
| Purity:
99.59% |
Supply Ability:
10g |
| Release date:
2024/11/20 |
Product Introduction
Bioactivity
| Name | HSR6071 |
| Description | HSR6071 is a novel orally active and potent anti-allergic agent with inhibitory effects on passive cutaneous anaphylaxis. HSR6071 showed anti-asthmatic activity in a rat model of experimental asthma. |
| In vivo | HSR-6071 (0.01-0.1 mg/kg; i.v.) inhibits experimental asthma induced by IgE antibody in rats in a dose-dependent manner. Additionally, HSR-6071 (0.3, 1.3 mg/kg; i.v.) prevents bronchoconstriction mediated by IgE or IgG antibody in guinea pigs. The compound inhibits cyclic AMP phosphodiesterase activity and induces relaxation of the guinea pig isolated trachea[1].With an IC50 of 0.46 nM, HSR-6071 inhibits IgE-mediated histamine release. Its effectiveness is observed not only through intravenous (i.v.) administration but also through oral (p.o.) administration in IgE-mediated passive cutaneous anaphylaxis (PCA) in rats. The most potent inhibition with HSR-6071 occurs when administered orally 5 minutes before the antigen challenge, indicating rapid absorption through the gastrointestinal tract[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 20 mg/mL (76.85 mM), Sonication is recommended.
|
| Keywords | HSR 6071 | HSR6071 | HSR-6071 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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