Hexahydrocurcumin NEW
| Price | $122 | $297 | $439 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Hexahydrocurcumin | CAS No.: 36062-05-2 |
| Purity: 99.77% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Hexahydrocurcumin |
| Description | Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1. |
| Cell Research | Cell Line: HT-29 cells. Concentration: 0 μM, 5 μM, 10 μM, 25 μM. Incubation Time: 24 hours or 48 hours [1] |
| Animal Research | Animal Model: Male Wistar rats (100-120 g) injected with dimethylhydrazine (DMH). Dosage: 50 mg/kg. Administration: Oral administration; daily; for 16 weeks [3] |
| In vitro | Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) significantly decreased HT-29 colon cancer cell viability in a time- and concentration-dependent manner, with IC50 values of 77.05 μM at 24 hours and 56.95 μM at 48 hours. When combined with 5-fluorouracil (5-FU; 5 μM), Hexahydrocurcumin markedly reduced COX-2 expression without altering COX-1 levels [1]. Moreover, Hexahydrocurcumin (7-14 μM; 24 hours) attenuated LPS-induced prostaglandin E2 (PGE2) increase in murine macrophages (RAW 264.7) in a concentration-dependent manner [2]. |
| In vivo | In colon cancer rats, Hexahydrocurcumin (50 mg/kg; oral administration; daily; for 16 weeks; male Wistar rats) treatment significantly reduces the numbers of aberrant crypt foci. Hexahydrocurcumin also markedly decreases COX-2 protein expression [3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (120.18 mM), Sonication is recommended. |
| Keywords | inhibit | Reactive Oxygen Species | COX | Cyclooxygenase | Inhibitor | Hexahydrocurcumin |
| Inhibitors Related | Sodium Thiocyanate | Imeglimin hydrochloride | Bismuth Subsalicylate | Ibuprofen | L-Ascorbic acid | Acetaminophen | Glucosamine | Diclofenac Potassium | Lycopene | Naringenin | Paradol | Salicylic acid |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Food as Medicine Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $0.00/1KG |
VIP3Y
|
Henan Aochuang Chemical Co.,Ltd.
|
2022-10-13 | |
| $0.00/5mg |
Shanghai Standard Technology Co., Ltd.
|
2020-05-09 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY