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Postion:Product Catalog >H1k
H1k
  • H1k

H1k NEW

Price $195 $483 $692
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-06

Product Details

Product Name: H1k Purity: 98.38%
Supply Ability: 10g Release date: 2024/11/06

Product Introduction

Bioactivity

名稱(chēng)H1k
描述H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulates the expression of cyclin-dependent kinase (CDK1) and cyclin B1.
體外活性H1k (72 h) exhibits anti-proliferative activity against LS-180, HepG-2, SGC-7901, A549, and MDA-MB-231 cells, with IC50 values of 2.9, 9.6, 12.1, 14.8, and 20.5 μM respectively [1].H1k (0-50 μM; 24 h) triggers significant G2-M arrest in MDA-MB-231 and SGC-7901 cells in a dose-dependent manner [1]. H1k (0-20 μM; 6 h; MDA-MB-231 cells) induces autophagy to exert its anti-proliferative activity, with lysosomes being its functional target [1].
存儲(chǔ)條件Shipping with blue ice.
溶解度DMSO : 3.9 mg/mL (10 mM), Sonication is recommended.
相關(guān)產(chǎn)品Ribociclib | Ro-3306 | GSK 3 Inhibitor IX | Rafoxanide | Palbociclib monohydrochloride | CASIN | Palbociclib | GW 441756 | Sodium Oxamate | Abemaciclib | Dinaciclib | Abemaciclib methanesulfonate
相關(guān)庫(kù)經(jīng)典已知活性庫(kù) | 激酶抑制劑庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù)

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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